Anti-IL3RA/ CD123/ IL3RY monoclonal antibody

Anti-IL3RA/ CD123/ IL3RY antibody for FACS & in-vivo assay

Target products collectionGo to IL3RA/IL3RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T71377-Ab-1/ GM-Tg-hg-T71377-Ab-2Anti-Human IL3RA monoclonal antibodyHuman
GM-Tg-rg-T71377-Ab-1/ GM-Tg-rg-T71377-Ab-2Anti-Rat IL3RA monoclonal antibodyRat
GM-Tg-mg-T71377-Ab-1/ GM-Tg-mg-T71377-Ab-2Anti-Mouse IL3RA monoclonal antibodyMouse
GM-Tg-cynog-T71377-Ab-1/ GM-Tg-cynog-T71377-Ab-2Anti-Cynomolgus/ Rhesus macaque IL3RA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T71377-Ab-1/ GM-Tg-felg-T71377-Ab-2Anti-Feline IL3RA monoclonal antibodyFeline
GM-Tg-cang-T71377-Ab-1/ GM-Tg-cang-T71377-Ab-2Anti-Canine IL3RA monoclonal antibodyCanine
GM-Tg-bovg-T71377-Ab-1/ GM-Tg-bovg-T71377-Ab-2Anti-Bovine IL3RA monoclonal antibodyBovine
GM-Tg-equg-T71377-Ab-1/ GM-Tg-equg-T71377-Ab-2Anti-Equine IL3RA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T71377-Ab-1/ GM-Tg-hg-T71377-Ab-2; GM-Tg-rg-T71377-Ab-1/ GM-Tg-rg-T71377-Ab-2;
GM-Tg-mg-T71377-Ab-1/ GM-Tg-mg-T71377-Ab-2; GM-Tg-cynog-T71377-Ab-1/ GM-Tg-cynog-T71377-Ab-2;
GM-Tg-felg-T71377-Ab-1/ GM-Tg-felg-T71377-Ab-2; GM-Tg-cang-T71377-Ab-1/ GM-Tg-cang-T71377-Ab-2;
GM-Tg-bovg-T71377-Ab-1/ GM-Tg-bovg-T71377-Ab-2; GM-Tg-equg-T71377-Ab-1/ GM-Tg-equg-T71377-Ab-2
Products NameAnti-IL3RA monoclonal antibody
Formatmab
Target NameIL3RA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL3RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-545Pre-Made Talacotuzumab biosimilar, Whole mAb, Anti-IL3RA Antibody: Anti-IL3R/CD123/IL3RX/IL3RY/hIL-3Ra therapeutic antibody
    BiosimilarGMP-Bios-ab-686Pre-Made Pivekimab biosimilar, Whole mAb, Anti-IL3RA Antibody: Anti-IL3R/CD123/IL3RX/IL3RY/hIL-3Ra therapeutic antibody
    BiosimilarGMP-Bios-ab-619Pre-Made Vibecotamab biosimilar, Bispecific Mixed mAb and scFv, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody
    BiosimilarGMP-Bios-INN-961Pre-Made Pivekimab Sunirine Biosimilar, Whole Mab Adc, Anti-Il3Ra Antibody: Anti-CD123/IL3R/IL3RX/IL3RY/hIL-3Ra therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-218Pre-Made Flotetuzumab biosimilar, Bispecific scFv with Crossover, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species IL3RA/ CD123/ IL3RY VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T71377
    Target NameIL3RA
    Gene ID3563,246144,106995138,609293,105261394,100299249
    Gene Symbol and SynonymsCD123,Cyrl,hIL-3Ra,IL-3R-alpha,IL3R,IL3RA,IL3RAY,IL3RX,IL3RY
    Uniprot AccessionP26951
    Uniprot Entry NameIL3RA_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000185291
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IL3RA, gene name: IL3RA, also named as CD123, IL3RY, IL3RX, IL3RY, hIL-3Ra, IL3RA. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.