Anti-IL3RA/ CD123/ IL3RY monoclonal antibody
Anti-IL3RA/ CD123/ IL3RY antibody for FACS & in-vivo assay
Go to IL3RA/IL3RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T71377-Ab-1/ GM-Tg-hg-T71377-Ab-2 | Anti-Human IL3RA monoclonal antibody | Human |
GM-Tg-rg-T71377-Ab-1/ GM-Tg-rg-T71377-Ab-2 | Anti-Rat IL3RA monoclonal antibody | Rat |
GM-Tg-mg-T71377-Ab-1/ GM-Tg-mg-T71377-Ab-2 | Anti-Mouse IL3RA monoclonal antibody | Mouse |
GM-Tg-cynog-T71377-Ab-1/ GM-Tg-cynog-T71377-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL3RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T71377-Ab-1/ GM-Tg-felg-T71377-Ab-2 | Anti-Feline IL3RA monoclonal antibody | Feline |
GM-Tg-cang-T71377-Ab-1/ GM-Tg-cang-T71377-Ab-2 | Anti-Canine IL3RA monoclonal antibody | Canine |
GM-Tg-bovg-T71377-Ab-1/ GM-Tg-bovg-T71377-Ab-2 | Anti-Bovine IL3RA monoclonal antibody | Bovine |
GM-Tg-equg-T71377-Ab-1/ GM-Tg-equg-T71377-Ab-2 | Anti-Equine IL3RA monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T71377-Ab-1/ GM-Tg-hg-T71377-Ab-2; GM-Tg-rg-T71377-Ab-1/ GM-Tg-rg-T71377-Ab-2; GM-Tg-mg-T71377-Ab-1/ GM-Tg-mg-T71377-Ab-2; GM-Tg-cynog-T71377-Ab-1/ GM-Tg-cynog-T71377-Ab-2; GM-Tg-felg-T71377-Ab-1/ GM-Tg-felg-T71377-Ab-2; GM-Tg-cang-T71377-Ab-1/ GM-Tg-cang-T71377-Ab-2; GM-Tg-bovg-T71377-Ab-1/ GM-Tg-bovg-T71377-Ab-2; GM-Tg-equg-T71377-Ab-1/ GM-Tg-equg-T71377-Ab-2 |
Products Name | Anti-IL3RA monoclonal antibody |
Format | mab |
Target Name | IL3RA |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-IL3RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
Target ID | GM-T71377 |
Target Name | IL3RA |
Gene ID | 3563,246144,106995138,609293,105261394,100299249 |
Gene Symbol and Synonyms | CD123,Cyrl,hIL-3Ra,IL-3R-alpha,IL3R,IL3RA,IL3RAY,IL3RX,IL3RY |
Uniprot Accession | P26951 |
Uniprot Entry Name | IL3RA_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000185291 |
Target Classification | Checkpoint-Immuno Oncology |
The target: IL3RA, gene name: IL3RA, also named as CD123, IL3RY, IL3RX, IL3RY, hIL-3Ra, IL3RA. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.