Anti-CSF2R/ CSF2RA/ CD116 monoclonal antibody

Anti-CSF2R/ CSF2RA/ CD116 antibody for FACS & in-vivo assay

Target products collectionGo to CSF2RA/CSF2RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T73097-Ab-1/ GM-Tg-hg-T73097-Ab-2Anti-Human CSF2RA monoclonal antibodyHuman
GM-Tg-rg-T73097-Ab-1/ GM-Tg-rg-T73097-Ab-2Anti-Rat CSF2RA monoclonal antibodyRat
GM-Tg-mg-T73097-Ab-1/ GM-Tg-mg-T73097-Ab-2Anti-Mouse CSF2RA monoclonal antibodyMouse
GM-Tg-cynog-T73097-Ab-1/ GM-Tg-cynog-T73097-Ab-2Anti-Cynomolgus/ Rhesus macaque CSF2RA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T73097-Ab-1/ GM-Tg-felg-T73097-Ab-2Anti-Feline CSF2RA monoclonal antibodyFeline
GM-Tg-cang-T73097-Ab-1/ GM-Tg-cang-T73097-Ab-2Anti-Canine CSF2RA monoclonal antibodyCanine
GM-Tg-bovg-T73097-Ab-1/ GM-Tg-bovg-T73097-Ab-2Anti-Bovine CSF2RA monoclonal antibodyBovine
GM-Tg-equg-T73097-Ab-1/ GM-Tg-equg-T73097-Ab-2Anti-Equine CSF2RA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T73097-Ab-1/ GM-Tg-hg-T73097-Ab-2; GM-Tg-rg-T73097-Ab-1/ GM-Tg-rg-T73097-Ab-2;
GM-Tg-mg-T73097-Ab-1/ GM-Tg-mg-T73097-Ab-2; GM-Tg-cynog-T73097-Ab-1/ GM-Tg-cynog-T73097-Ab-2;
GM-Tg-felg-T73097-Ab-1/ GM-Tg-felg-T73097-Ab-2; GM-Tg-cang-T73097-Ab-1/ GM-Tg-cang-T73097-Ab-2;
GM-Tg-bovg-T73097-Ab-1/ GM-Tg-bovg-T73097-Ab-2; GM-Tg-equg-T73097-Ab-1/ GM-Tg-equg-T73097-Ab-2
Products NameAnti-CSF2RA monoclonal antibody
Formatmab
Target NameCSF2RA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CSF2RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-986Pre-Made Sargramostim Biosimilar, Recombinant Protein targeting CSF2RA: Recombinant therapeutic protein targeting CD116/CDw116/CSF2R/CSF2RAX/CSF2RAY/CSF2RX/CSF2RY/GM-CSF-R-alpha/GMCSFR/GMCSFR-alpha/GMR/GMR-alpha/SMDP4/alphaGMR
    BiosimilarGMP-Bios-ab-339Pre-Made Mavrilimumab biosimilar, Whole mAb, Anti-CSF2RA Antibody: Anti-GMR/CD116/CSF2R/SMDP4/CDw116GMR-alpha/GMCSFR-alpha/GM-CSF-R-alpha therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CSF2R/ CSF2RA/ CD116 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP002066human CSF2RA Lentivirus particle
    ORF Viral VectorpGMLP002066human CSF2RA Lentivirus plasmid
    ORF Viral VectorpGMLPm003833mouse Csf2ra Lentivirus plasmid
    ORF Viral VectorvGMLPm003833mouse Csf2ra Lentivirus particle


    Target information

    Target IDGM-T73097
    Target NameCSF2RA
    Gene ID1438,100336606
    Gene Symbol and SynonymsalphaGMR,CD116,CDw116,CSF2R,CSF2RA,CSF2RAX,CSF2RAY,CSF2RX,CSF2RY,GM-CSF-R-alpha,GMCSFR,GMCSFR-alpha,GMR,GMR-alpha,SMDP4
    Uniprot AccessionP15509
    Uniprot Entry NameCSF2R_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000198223
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CSF2RA, gene name: CSF2RA, also named as CD116, CDw116, CSF2RX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, alphaGMR, CSF2RA. The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.