Anti-CSF2R/ CSF2RA/ CD116 monoclonal antibody
Anti-CSF2R/ CSF2RA/ CD116 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T73097-Ab-1/ GM-Tg-hg-T73097-Ab-2 | Anti-Human CSF2RA monoclonal antibody | Human |
GM-Tg-rg-T73097-Ab-1/ GM-Tg-rg-T73097-Ab-2 | Anti-Rat CSF2RA monoclonal antibody | Rat |
GM-Tg-mg-T73097-Ab-1/ GM-Tg-mg-T73097-Ab-2 | Anti-Mouse CSF2RA monoclonal antibody | Mouse |
GM-Tg-cynog-T73097-Ab-1/ GM-Tg-cynog-T73097-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CSF2RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T73097-Ab-1/ GM-Tg-felg-T73097-Ab-2 | Anti-Feline CSF2RA monoclonal antibody | Feline |
GM-Tg-cang-T73097-Ab-1/ GM-Tg-cang-T73097-Ab-2 | Anti-Canine CSF2RA monoclonal antibody | Canine |
GM-Tg-bovg-T73097-Ab-1/ GM-Tg-bovg-T73097-Ab-2 | Anti-Bovine CSF2RA monoclonal antibody | Bovine |
GM-Tg-equg-T73097-Ab-1/ GM-Tg-equg-T73097-Ab-2 | Anti-Equine CSF2RA monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T73097-Ab-1/ GM-Tg-hg-T73097-Ab-2; GM-Tg-rg-T73097-Ab-1/ GM-Tg-rg-T73097-Ab-2; GM-Tg-mg-T73097-Ab-1/ GM-Tg-mg-T73097-Ab-2; GM-Tg-cynog-T73097-Ab-1/ GM-Tg-cynog-T73097-Ab-2; GM-Tg-felg-T73097-Ab-1/ GM-Tg-felg-T73097-Ab-2; GM-Tg-cang-T73097-Ab-1/ GM-Tg-cang-T73097-Ab-2; GM-Tg-bovg-T73097-Ab-1/ GM-Tg-bovg-T73097-Ab-2; GM-Tg-equg-T73097-Ab-1/ GM-Tg-equg-T73097-Ab-2 |
Products Name | Anti-CSF2RA monoclonal antibody |
Format | mab |
Target Name | CSF2RA |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CSF2RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-986 | Pre-Made Sargramostim Biosimilar, Recombinant Protein targeting CSF2RA: Recombinant therapeutic protein targeting CD116/CDw116/CSF2R/CSF2RAX/CSF2RAY/CSF2RX/CSF2RY/GM-CSF-R-alpha/GMCSFR/GMCSFR-alpha/GMR/GMR-alpha/SMDP4/alphaGMR |
Biosimilar | GMP-Bios-ab-339 | Pre-Made Mavrilimumab biosimilar, Whole mAb, Anti-CSF2RA Antibody: Anti-GMR/CD116/CSF2R/SMDP4/CDw116GMR-alpha/GMCSFR-alpha/GM-CSF-R-alpha therapeutic antibody |
Target Antigen | Products Developing | Multi-species CSF2R/ CSF2RA/ CD116 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP002066 | human CSF2RA Lentivirus particle |
ORF Viral Vector | pGMLP002066 | human CSF2RA Lentivirus plasmid |
ORF Viral Vector | pGMLPm003833 | mouse Csf2ra Lentivirus plasmid |
ORF Viral Vector | vGMLPm003833 | mouse Csf2ra Lentivirus particle |
Target information
Target ID | GM-T73097 |
Target Name | CSF2RA |
Gene ID | 1438,100336606 |
Gene Symbol and Synonyms | alphaGMR,CD116,CDw116,CSF2R,CSF2RA,CSF2RAX,CSF2RAY,CSF2RX,CSF2RY,GM-CSF-R-alpha,GMCSFR,GMCSFR-alpha,GMR,GMR-alpha,SMDP4 |
Uniprot Accession | P15509 |
Uniprot Entry Name | CSF2R_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000198223 |
Target Classification | Checkpoint-Immuno Oncology |
The target: CSF2RA, gene name: CSF2RA, also named as CD116, CDw116, CSF2RX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, alphaGMR, CSF2RA. The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.