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Anti-FLT3/ FLT-3/ CD135 monoclonal antibody
Anti-FLT3/ FLT-3/ CD135 antibody for FACS & in-vivo assay
Go to FLT-3/FLT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T74312-Ab-1/ GM-Tg-hg-T74312-Ab-2 | Anti-Human FLT-3/FLT3 monoclonal antibody | Human |
| GM-Tg-rg-T74312-Ab-1/ GM-Tg-rg-T74312-Ab-2 | Anti-Rat FLT-3/FLT3 monoclonal antibody | Rat |
| GM-Tg-mg-T74312-Ab-1/ GM-Tg-mg-T74312-Ab-2 | Anti-Mouse FLT-3/FLT3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T74312-Ab-1/ GM-Tg-cynog-T74312-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FLT-3/FLT3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T74312-Ab-1/ GM-Tg-felg-T74312-Ab-2 | Anti-Feline FLT-3/FLT3 monoclonal antibody | Feline |
| GM-Tg-cang-T74312-Ab-1/ GM-Tg-cang-T74312-Ab-2 | Anti-Canine FLT-3/FLT3 monoclonal antibody | Canine |
| GM-Tg-bovg-T74312-Ab-1/ GM-Tg-bovg-T74312-Ab-2 | Anti-Bovine FLT-3/FLT3 monoclonal antibody | Bovine |
| GM-Tg-equg-T74312-Ab-1/ GM-Tg-equg-T74312-Ab-2 | Anti-Equine FLT-3/FLT3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T74312-Ab-1/ GM-Tg-hg-T74312-Ab-2; GM-Tg-rg-T74312-Ab-1/ GM-Tg-rg-T74312-Ab-2; GM-Tg-mg-T74312-Ab-1/ GM-Tg-mg-T74312-Ab-2; GM-Tg-cynog-T74312-Ab-1/ GM-Tg-cynog-T74312-Ab-2; GM-Tg-felg-T74312-Ab-1/ GM-Tg-felg-T74312-Ab-2; GM-Tg-cang-T74312-Ab-1/ GM-Tg-cang-T74312-Ab-2; GM-Tg-bovg-T74312-Ab-1/ GM-Tg-bovg-T74312-Ab-2; GM-Tg-equg-T74312-Ab-1/ GM-Tg-equg-T74312-Ab-2 |
| Products Name | Anti-FLT-3/FLT3 monoclonal antibody |
| Format | mab |
| Target Name | FLT-3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FLT-3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FLT3/ FLT-3/ CD135 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000233 | mouse Flt3 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000159 | mouse Flt3 AAV plasmid |
| ORF Viral Vector | vGMAD000233 | mouse Flt3 Adenovirus particle |
| ORF Viral Vector | vGMAAV000159 | mouse Flt3 AAV particle |
Target information
| Target ID | GM-T74312 |
| Target Name | FLT-3 |
| Gene ID | 2322,14255,140635,721712,486025,101099264,512700,100061780 |
| Gene Symbol and Synonyms | B230315G04,CD135,FLK-2,FLK2,Flt-3,FLT3,Ly72,STK1,wmfl |
| Uniprot Accession | P36888 |
| Uniprot Entry Name | FLT3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000122025 |
| Target Classification | Checkpoint-Immuno Oncology, Kinase, Tumor-associated antigen (TAA) |
The target: FLT-3, gene name: FLT3, also named as CD135, FLK-2, FLK2, STK1. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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