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Anti-KCND3/ BRGDA9L/ KCND3S monoclonal antibody
Anti-KCND3/ BRGDA9L/ KCND3S antibody for FACS & in-vivo assay
Go to KCND3/KCND3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T74500-Ab-1/ GM-Tg-hg-T74500-Ab-2 | Anti-Human KCND3 monoclonal antibody | Human |
| GM-Tg-rg-T74500-Ab-1/ GM-Tg-rg-T74500-Ab-2 | Anti-Rat KCND3 monoclonal antibody | Rat |
| GM-Tg-mg-T74500-Ab-1/ GM-Tg-mg-T74500-Ab-2 | Anti-Mouse KCND3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T74500-Ab-1/ GM-Tg-cynog-T74500-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCND3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T74500-Ab-1/ GM-Tg-felg-T74500-Ab-2 | Anti-Feline KCND3 monoclonal antibody | Feline |
| GM-Tg-cang-T74500-Ab-1/ GM-Tg-cang-T74500-Ab-2 | Anti-Canine KCND3 monoclonal antibody | Canine |
| GM-Tg-bovg-T74500-Ab-1/ GM-Tg-bovg-T74500-Ab-2 | Anti-Bovine KCND3 monoclonal antibody | Bovine |
| GM-Tg-equg-T74500-Ab-1/ GM-Tg-equg-T74500-Ab-2 | Anti-Equine KCND3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T74500-Ab-1/ GM-Tg-hg-T74500-Ab-2; GM-Tg-rg-T74500-Ab-1/ GM-Tg-rg-T74500-Ab-2; GM-Tg-mg-T74500-Ab-1/ GM-Tg-mg-T74500-Ab-2; GM-Tg-cynog-T74500-Ab-1/ GM-Tg-cynog-T74500-Ab-2; GM-Tg-felg-T74500-Ab-1/ GM-Tg-felg-T74500-Ab-2; GM-Tg-cang-T74500-Ab-1/ GM-Tg-cang-T74500-Ab-2; GM-Tg-bovg-T74500-Ab-1/ GM-Tg-bovg-T74500-Ab-2; GM-Tg-equg-T74500-Ab-1/ GM-Tg-equg-T74500-Ab-2 |
| Products Name | Anti-KCND3 monoclonal antibody |
| Format | mab |
| Target Name | KCND3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCND3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCND3/ BRGDA9L/ KCND3S VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAAV000111 | rat Kcnd3 AAV plasmid |
| ORF Viral Vector | vGMAAV000111 | rat Kcnd3 AAV particle |
Target information
| Target ID | GM-T74500 |
| Target Name | KCND3 |
| Gene ID | 3752,56543,65195,641437,403758,101095595,539739,100058973 |
| Gene Symbol and Synonyms | BRGDA9,KCND3,KCND3L,KCND3S,Kncd3,KSHIVB,KV4.3,SCA19,SCA22 |
| Uniprot Accession | Q9UK17,Q62897 |
| Uniprot Entry Name | KCND3_HUMAN,KCND3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171385 |
| Target Classification | Ion Channel |
The target: KCND3, gene name: KCND3, also named as BRGDA9L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, KCND3. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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