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Anti-C1S/ EDSPD2 functional antibody
Anti-C1S/ EDSPD2 functional antibody for cell culture, ELISA & in-vivo assay
Go to C1S/C1S products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T76024-Ab-1/ GM-Tg-hg-T76024-Ab-2 | Anti-Human C1S monoclonal antibody | Human |
| GM-Tg-rg-T76024-Ab-1/ GM-Tg-rg-T76024-Ab-2 | Anti-Rat C1S monoclonal antibody | Rat |
| GM-Tg-mg-T76024-Ab-1/ GM-Tg-mg-T76024-Ab-2 | Anti-Mouse C1S monoclonal antibody | Mouse |
| GM-Tg-cynog-T76024-Ab-1/ GM-Tg-cynog-T76024-Ab-2 | Anti-Cynomolgus/ Rhesus macaque C1S monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T76024-Ab-1/ GM-Tg-felg-T76024-Ab-2 | Anti-Feline C1S monoclonal antibody | Feline |
| GM-Tg-cang-T76024-Ab-1/ GM-Tg-cang-T76024-Ab-2 | Anti-Canine C1S monoclonal antibody | Canine |
| GM-Tg-bovg-T76024-Ab-1/ GM-Tg-bovg-T76024-Ab-2 | Anti-Bovine C1S monoclonal antibody | Bovine |
| GM-Tg-equg-T76024-Ab-1/ GM-Tg-equg-T76024-Ab-2 | Anti-Equine C1S monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T76024-Ab-1/ GM-Tg-hg-T76024-Ab-2; GM-Tg-rg-T76024-Ab-1/ GM-Tg-rg-T76024-Ab-2; GM-Tg-mg-T76024-Ab-1/ GM-Tg-mg-T76024-Ab-2; GM-Tg-cynog-T76024-Ab-1/ GM-Tg-cynog-T76024-Ab-2; GM-Tg-felg-T76024-Ab-1/ GM-Tg-felg-T76024-Ab-2; GM-Tg-cang-T76024-Ab-1/ GM-Tg-cang-T76024-Ab-2; GM-Tg-bovg-T76024-Ab-1/ GM-Tg-bovg-T76024-Ab-2; GM-Tg-equg-T76024-Ab-1/ GM-Tg-equg-T76024-Ab-2 |
| Products Name | Anti-C1S monoclonal antibody |
| Format | mab |
| Target Name | C1S |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-C1S benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-537 | Pre-Made Sutimlimab biosimilar, Whole mAb, Anti-C1S Antibody: Anti-EDSPD2 therapeutic antibody |
| Target Antigen | GM-Tg-g-T76024-Ag-1 | Recombinant multi-species C1S/ EDSPD2 protein |
| ORF Viral Vector | pGMLP001461 | human C1S Lentivirus plasmid |
| ORF Viral Vector | vGMLP001461 | human C1S Lentivirus particle |
| ORF Viral Vector | pGMLPm004825 | mouse C1s1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004825 | mouse C1s1 Lentivirus particle |
Target information
| Target ID | GM-T76024 |
| Target Name | C1S |
| Gene ID | 716,317677,192262,714589,486714,101088676,767827,100060261 |
| Gene Symbol and Synonyms | C1S,C1s2,C1sb,CC1s,EDSPD2,EG317677,Gm5077,r-gsp |
| Uniprot Accession | P09871,Q6P6T1,Q0VCX1 |
| Uniprot Entry Name | C1S_HUMAN,C1S_RAT,C1S_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000182326 |
| Target Classification | N/A |
The target: C1S, gene name: C1S, also named as EDSPD2. This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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