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Anti-EST1/ CES1/ ACAT functional antibody
Anti-EST1/ CES1/ ACAT functional antibody for cell culture, ELISA & in-vivo assay
Go to CES1/CES1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T76369-Ab-1/ GM-Tg-hg-T76369-Ab-2 | Anti-Human CES1 monoclonal antibody | Human |
| GM-Tg-rg-T76369-Ab-1/ GM-Tg-rg-T76369-Ab-2 | Anti-Rat CES1 monoclonal antibody | Rat |
| GM-Tg-mg-T76369-Ab-1/ GM-Tg-mg-T76369-Ab-2 | Anti-Mouse CES1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T76369-Ab-1/ GM-Tg-cynog-T76369-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CES1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T76369-Ab-1/ GM-Tg-felg-T76369-Ab-2 | Anti-Feline CES1 monoclonal antibody | Feline |
| GM-Tg-cang-T76369-Ab-1/ GM-Tg-cang-T76369-Ab-2 | Anti-Canine CES1 monoclonal antibody | Canine |
| GM-Tg-bovg-T76369-Ab-1/ GM-Tg-bovg-T76369-Ab-2 | Anti-Bovine CES1 monoclonal antibody | Bovine |
| GM-Tg-equg-T76369-Ab-1/ GM-Tg-equg-T76369-Ab-2 | Anti-Equine CES1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T76369-Ab-1/ GM-Tg-hg-T76369-Ab-2; GM-Tg-rg-T76369-Ab-1/ GM-Tg-rg-T76369-Ab-2; GM-Tg-mg-T76369-Ab-1/ GM-Tg-mg-T76369-Ab-2; GM-Tg-cynog-T76369-Ab-1/ GM-Tg-cynog-T76369-Ab-2; GM-Tg-felg-T76369-Ab-1/ GM-Tg-felg-T76369-Ab-2; GM-Tg-cang-T76369-Ab-1/ GM-Tg-cang-T76369-Ab-2; GM-Tg-bovg-T76369-Ab-1/ GM-Tg-bovg-T76369-Ab-2; GM-Tg-equg-T76369-Ab-1/ GM-Tg-equg-T76369-Ab-2 |
| Products Name | Anti-CES1 monoclonal antibody |
| Format | mab |
| Target Name | CES1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CES1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T76369-Ag-1 | Recombinant multi-species EST1/ CES1/ ACAT protein |
Target information
| Target ID | GM-T76369 |
| Target Name | CES1 |
| Gene ID | 1066,403643,493774 |
| Gene Symbol and Synonyms | ACAT,CE-1,CEH,CES-K1,CES1,CES2,CESDD1,hCE-1,HMSE,HMSE1,PCE-1,REH,SES1,TGH |
| Uniprot Accession | P23141 |
| Uniprot Entry Name | EST1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000198848 |
| Target Classification | N/A |
The target: CES1, gene name: CES1, also named as ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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