Anti-NMDE2/ NMDAR2B/ GRIN2B monoclonal antibody
Anti-NMDE2/ NMDAR2B/ GRIN2B antibody for FACS & in-vivo assay
Go to NMDAR2B/GRIN2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T76414-Ab-1/ GM-Tg-hg-T76414-Ab-2 | Anti-Human NMDAR2B/GRIN2B monoclonal antibody | Human |
GM-Tg-rg-T76414-Ab-1/ GM-Tg-rg-T76414-Ab-2 | Anti-Rat NMDAR2B/GRIN2B monoclonal antibody | Rat |
GM-Tg-mg-T76414-Ab-1/ GM-Tg-mg-T76414-Ab-2 | Anti-Mouse NMDAR2B/GRIN2B monoclonal antibody | Mouse |
GM-Tg-cynog-T76414-Ab-1/ GM-Tg-cynog-T76414-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NMDAR2B/GRIN2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T76414-Ab-1/ GM-Tg-felg-T76414-Ab-2 | Anti-Feline NMDAR2B/GRIN2B monoclonal antibody | Feline |
GM-Tg-cang-T76414-Ab-1/ GM-Tg-cang-T76414-Ab-2 | Anti-Canine NMDAR2B/GRIN2B monoclonal antibody | Canine |
GM-Tg-bovg-T76414-Ab-1/ GM-Tg-bovg-T76414-Ab-2 | Anti-Bovine NMDAR2B/GRIN2B monoclonal antibody | Bovine |
GM-Tg-equg-T76414-Ab-1/ GM-Tg-equg-T76414-Ab-2 | Anti-Equine NMDAR2B/GRIN2B monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T76414-Ab-1/ GM-Tg-hg-T76414-Ab-2; GM-Tg-rg-T76414-Ab-1/ GM-Tg-rg-T76414-Ab-2; GM-Tg-mg-T76414-Ab-1/ GM-Tg-mg-T76414-Ab-2; GM-Tg-cynog-T76414-Ab-1/ GM-Tg-cynog-T76414-Ab-2; GM-Tg-felg-T76414-Ab-1/ GM-Tg-felg-T76414-Ab-2; GM-Tg-cang-T76414-Ab-1/ GM-Tg-cang-T76414-Ab-2; GM-Tg-bovg-T76414-Ab-1/ GM-Tg-bovg-T76414-Ab-2; GM-Tg-equg-T76414-Ab-1/ GM-Tg-equg-T76414-Ab-2 |
Products Name | Anti-NMDAR2B/GRIN2B monoclonal antibody |
Format | mab |
Target Name | NMDAR2B |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-NMDAR2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species NMDE2/ NMDAR2B/ GRIN2B VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T76414 |
Target Name | NMDAR2B |
Gene ID | 2904,14812,24410,698571,494009,101094356,537804,100063746 |
Gene Symbol and Synonyms | DEE27,EIEE27,GluN2B,GluRepsilon2,GRIN2B,hNR3,MRD6,NMDAR2B,NR2B,NR3 |
Uniprot Accession | Q13224,Q00960,Q5R1P3 |
Uniprot Entry Name | NMDE2_HUMAN,NMDE2_RAT,NMDE2_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000273079 |
Target Classification | N/A |
The target: NMDAR2B, gene name: GRIN2B, also named as EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3. This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.