Anti-NMDE2/ NMDAR2B/ GRIN2B monoclonal antibody

Anti-NMDE2/ NMDAR2B/ GRIN2B antibody for FACS & in-vivo assay

Target products collectionGo to NMDAR2B/GRIN2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T76414-Ab-1/ GM-Tg-hg-T76414-Ab-2Anti-Human NMDAR2B/GRIN2B monoclonal antibodyHuman
GM-Tg-rg-T76414-Ab-1/ GM-Tg-rg-T76414-Ab-2Anti-Rat NMDAR2B/GRIN2B monoclonal antibodyRat
GM-Tg-mg-T76414-Ab-1/ GM-Tg-mg-T76414-Ab-2Anti-Mouse NMDAR2B/GRIN2B monoclonal antibodyMouse
GM-Tg-cynog-T76414-Ab-1/ GM-Tg-cynog-T76414-Ab-2Anti-Cynomolgus/ Rhesus macaque NMDAR2B/GRIN2B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T76414-Ab-1/ GM-Tg-felg-T76414-Ab-2Anti-Feline NMDAR2B/GRIN2B monoclonal antibodyFeline
GM-Tg-cang-T76414-Ab-1/ GM-Tg-cang-T76414-Ab-2Anti-Canine NMDAR2B/GRIN2B monoclonal antibodyCanine
GM-Tg-bovg-T76414-Ab-1/ GM-Tg-bovg-T76414-Ab-2Anti-Bovine NMDAR2B/GRIN2B monoclonal antibodyBovine
GM-Tg-equg-T76414-Ab-1/ GM-Tg-equg-T76414-Ab-2Anti-Equine NMDAR2B/GRIN2B monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T76414-Ab-1/ GM-Tg-hg-T76414-Ab-2; GM-Tg-rg-T76414-Ab-1/ GM-Tg-rg-T76414-Ab-2;
GM-Tg-mg-T76414-Ab-1/ GM-Tg-mg-T76414-Ab-2; GM-Tg-cynog-T76414-Ab-1/ GM-Tg-cynog-T76414-Ab-2;
GM-Tg-felg-T76414-Ab-1/ GM-Tg-felg-T76414-Ab-2; GM-Tg-cang-T76414-Ab-1/ GM-Tg-cang-T76414-Ab-2;
GM-Tg-bovg-T76414-Ab-1/ GM-Tg-bovg-T76414-Ab-2; GM-Tg-equg-T76414-Ab-1/ GM-Tg-equg-T76414-Ab-2
Products NameAnti-NMDAR2B/GRIN2B monoclonal antibody
Formatmab
Target NameNMDAR2B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NMDAR2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NMDE2/ NMDAR2B/ GRIN2B VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T76414
    Target NameNMDAR2B
    Gene ID2904,14812,24410,698571,494009,101094356,537804,100063746
    Gene Symbol and SynonymsDEE27,EIEE27,GluN2B,GluRepsilon2,GRIN2B,hNR3,MRD6,NMDAR2B,NR2B,NR3
    Uniprot AccessionQ13224,Q00960,Q5R1P3
    Uniprot Entry NameNMDE2_HUMAN,NMDE2_RAT,NMDE2_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000273079
    Target ClassificationN/A

    The target: NMDAR2B, gene name: GRIN2B, also named as EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3. This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.