Anti-CD52/ CDW52/ EDDM5 monoclonal antibody

Anti-CD52/ CDW52/ EDDM5 antibody for FACS & in-vivo assay

Target products collectionGo to CD52/CD52 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T76630-Ab-1/ GM-Tg-hg-T76630-Ab-2Anti-Human CD52 monoclonal antibodyHuman
GM-Tg-rg-T76630-Ab-1/ GM-Tg-rg-T76630-Ab-2Anti-Rat CD52 monoclonal antibodyRat
GM-Tg-mg-T76630-Ab-1/ GM-Tg-mg-T76630-Ab-2Anti-Mouse CD52 monoclonal antibodyMouse
GM-Tg-cynog-T76630-Ab-1/ GM-Tg-cynog-T76630-Ab-2Anti-Cynomolgus/ Rhesus macaque CD52 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T76630-Ab-1/ GM-Tg-felg-T76630-Ab-2Anti-Feline CD52 monoclonal antibodyFeline
GM-Tg-cang-T76630-Ab-1/ GM-Tg-cang-T76630-Ab-2Anti-Canine CD52 monoclonal antibodyCanine
GM-Tg-bovg-T76630-Ab-1/ GM-Tg-bovg-T76630-Ab-2Anti-Bovine CD52 monoclonal antibodyBovine
GM-Tg-equg-T76630-Ab-1/ GM-Tg-equg-T76630-Ab-2Anti-Equine CD52 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T76630-Ab-1/ GM-Tg-hg-T76630-Ab-2; GM-Tg-rg-T76630-Ab-1/ GM-Tg-rg-T76630-Ab-2;
GM-Tg-mg-T76630-Ab-1/ GM-Tg-mg-T76630-Ab-2; GM-Tg-cynog-T76630-Ab-1/ GM-Tg-cynog-T76630-Ab-2;
GM-Tg-felg-T76630-Ab-1/ GM-Tg-felg-T76630-Ab-2; GM-Tg-cang-T76630-Ab-1/ GM-Tg-cang-T76630-Ab-2;
GM-Tg-bovg-T76630-Ab-1/ GM-Tg-bovg-T76630-Ab-2; GM-Tg-equg-T76630-Ab-1/ GM-Tg-equg-T76630-Ab-2
Products NameAnti-CD52 monoclonal antibody
Formatmab
Target NameCD52
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD52 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-015Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody
    BiosimilarGMP-Bios-ab-237Pre-Made Gatralimab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody
    BiosimilarGMP-Bios-ab-548Pre-Made Tamtuvetmab biosimilar, Canine Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CD52/ CDW52/ EDDM5 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004985human CD52 Lentivirus particle
    ORF Viral VectorpGMLP004985human CD52 Lentivirus plasmid
    ORF Viral VectorpGMLPm000572mouse Cd52 Lentivirus plasmid
    ORF Viral VectorvGMLPm000572mouse Cd52 Lentivirus particle


    Target information

    Target IDGM-T76630
    Target NameCD52
    Gene ID1043,23833,117054,714429,403918,101085645,507141,111772400
    Gene Symbol and SynonymsB7,B7-Ag,CAMPATH-1,CD52,CDW52,CE5,CLS1,EDDM5,HE5,MB7
    Uniprot AccessionP31358,Q63064,Q28896
    Uniprot Entry NameCD52_HUMAN,CD52_RAT,CD52_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000169442
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CD52, gene name: CD52, also named as CDW52, EDDM5. Involved in positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region and plasma membrane. Predicted to be intrinsic component of plasma membrane. Predicted to be active in sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.