Anti-COMT/ HEL-S-98n monoclonal antibody

Anti-COMT/ HEL-S-98n antibody for FACS & in-vivo assay

Target products collectionGo to COMT/COMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T76904-Ab-1/ GM-Tg-hg-T76904-Ab-2Anti-Human COMT monoclonal antibodyHuman
GM-Tg-rg-T76904-Ab-1/ GM-Tg-rg-T76904-Ab-2Anti-Rat COMT monoclonal antibodyRat
GM-Tg-mg-T76904-Ab-1/ GM-Tg-mg-T76904-Ab-2Anti-Mouse COMT monoclonal antibodyMouse
GM-Tg-cynog-T76904-Ab-1/ GM-Tg-cynog-T76904-Ab-2Anti-Cynomolgus/ Rhesus macaque COMT monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T76904-Ab-1/ GM-Tg-felg-T76904-Ab-2Anti-Feline COMT monoclonal antibodyFeline
GM-Tg-cang-T76904-Ab-1/ GM-Tg-cang-T76904-Ab-2Anti-Canine COMT monoclonal antibodyCanine
GM-Tg-bovg-T76904-Ab-1/ GM-Tg-bovg-T76904-Ab-2Anti-Bovine COMT monoclonal antibodyBovine
GM-Tg-equg-T76904-Ab-1/ GM-Tg-equg-T76904-Ab-2Anti-Equine COMT monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T76904-Ab-1/ GM-Tg-hg-T76904-Ab-2; GM-Tg-rg-T76904-Ab-1/ GM-Tg-rg-T76904-Ab-2;
GM-Tg-mg-T76904-Ab-1/ GM-Tg-mg-T76904-Ab-2; GM-Tg-cynog-T76904-Ab-1/ GM-Tg-cynog-T76904-Ab-2;
GM-Tg-felg-T76904-Ab-1/ GM-Tg-felg-T76904-Ab-2; GM-Tg-cang-T76904-Ab-1/ GM-Tg-cang-T76904-Ab-2;
GM-Tg-bovg-T76904-Ab-1/ GM-Tg-bovg-T76904-Ab-2; GM-Tg-equg-T76904-Ab-1/ GM-Tg-equg-T76904-Ab-2
Products NameAnti-COMT monoclonal antibody
Formatmab
Target NameCOMT
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-COMT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species COMT/ HEL-S-98n VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003872human COMT Lentivirus plasmid
    ORF Viral VectorpGMAP000064Human COMT Adenovirus plasmid
    ORF Viral VectorvGMLP003872human COMT Lentivirus particle
    ORF Viral VectorvGMAP000064Human COMT Adenovirus particle
    ORF Viral VectorpGMAP000020Human COMT Adenovirus plasmid
    ORF Viral VectorvGMAP000020Human COMT Adenovirus particle
    ORF Viral VectorpGMLPm000356mouse Comt Lentivirus plasmid
    ORF Viral VectorvGMLPm000356mouse Comt Lentivirus particle


    Target information

    Target IDGM-T76904
    Target NameCOMT
    Gene ID1312,12846,24267,712548,445450,101097022,618278
    Gene Symbol and SynonymsCOMT,Comt1,D16Wsu103e,D330014B15Rik,HEL-S-98n
    Uniprot AccessionP21964,P22734,A7MBI7
    Uniprot Entry NameCOMT_HUMAN,COMT_RAT,COMT_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseMalignant neoplasm of bladder, Schizophrenia
    Gene EnsemblENSG00000093010
    Target ClassificationN/A

    The target: COMT, gene name: COMT, also named as HEL-S-98n. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.