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Anti-HRH1/ H1R/ H1-R monoclonal antibody
Anti-HRH1/ H1R/ H1-R antibody for FACS & in-vivo assay
Go to H1R/HRH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T77913-Ab-1/ GM-Tg-hg-T77913-Ab-2 | Anti-Human H1R/HRH1 monoclonal antibody | Human |
| GM-Tg-rg-T77913-Ab-1/ GM-Tg-rg-T77913-Ab-2 | Anti-Rat H1R/HRH1 monoclonal antibody | Rat |
| GM-Tg-mg-T77913-Ab-1/ GM-Tg-mg-T77913-Ab-2 | Anti-Mouse H1R/HRH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T77913-Ab-1/ GM-Tg-cynog-T77913-Ab-2 | Anti-Cynomolgus/ Rhesus macaque H1R/HRH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T77913-Ab-1/ GM-Tg-felg-T77913-Ab-2 | Anti-Feline H1R/HRH1 monoclonal antibody | Feline |
| GM-Tg-cang-T77913-Ab-1/ GM-Tg-cang-T77913-Ab-2 | Anti-Canine H1R/HRH1 monoclonal antibody | Canine |
| GM-Tg-bovg-T77913-Ab-1/ GM-Tg-bovg-T77913-Ab-2 | Anti-Bovine H1R/HRH1 monoclonal antibody | Bovine |
| GM-Tg-equg-T77913-Ab-1/ GM-Tg-equg-T77913-Ab-2 | Anti-Equine H1R/HRH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T77913-Ab-1/ GM-Tg-hg-T77913-Ab-2; GM-Tg-rg-T77913-Ab-1/ GM-Tg-rg-T77913-Ab-2; GM-Tg-mg-T77913-Ab-1/ GM-Tg-mg-T77913-Ab-2; GM-Tg-cynog-T77913-Ab-1/ GM-Tg-cynog-T77913-Ab-2; GM-Tg-felg-T77913-Ab-1/ GM-Tg-felg-T77913-Ab-2; GM-Tg-cang-T77913-Ab-1/ GM-Tg-cang-T77913-Ab-2; GM-Tg-bovg-T77913-Ab-1/ GM-Tg-bovg-T77913-Ab-2; GM-Tg-equg-T77913-Ab-1/ GM-Tg-equg-T77913-Ab-2 |
| Products Name | Anti-H1R/HRH1 monoclonal antibody |
| Format | mab |
| Target Name | H1R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-H1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HRH1/ H1R/ H1-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003757 | human HRH1 Lentivirus particle |
| ORF Viral Vector | pGMLP003757 | human HRH1 Lentivirus plasmid |
Target information
| Target ID | GM-T77913 |
| Target Name | H1R |
| Gene ID | 3269,15465,24448,696359,403813,101088314,281231,100034110 |
| Gene Symbol and Synonyms | Bphs,H1,H1-R,H1R,HH1R,Hir,hisH1,Hisr,HRH1 |
| Uniprot Accession | P35367,P31390,P30546 |
| Uniprot Entry Name | HRH1_HUMAN,HRH1_RAT,HRH1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000196639 |
| Target Classification | GPCR |
The target: H1R, gene name: HRH1, also named as H1-R, H1R, HH1R, hisH1. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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