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Anti-IL5/ EDF/ IL-5 functional antibody
Anti-IL5/ EDF/ IL-5 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL5/IL5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T78585-Ab-1/ GM-Tg-hg-T78585-Ab-2 | Anti-Human IL5 monoclonal antibody | Human |
| GM-Tg-rg-T78585-Ab-1/ GM-Tg-rg-T78585-Ab-2 | Anti-Rat IL5 monoclonal antibody | Rat |
| GM-Tg-mg-T78585-Ab-1/ GM-Tg-mg-T78585-Ab-2 | Anti-Mouse IL5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T78585-Ab-1/ GM-Tg-cynog-T78585-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T78585-Ab-1/ GM-Tg-felg-T78585-Ab-2 | Anti-Feline IL5 monoclonal antibody | Feline |
| GM-Tg-cang-T78585-Ab-1/ GM-Tg-cang-T78585-Ab-2 | Anti-Canine IL5 monoclonal antibody | Canine |
| GM-Tg-bovg-T78585-Ab-1/ GM-Tg-bovg-T78585-Ab-2 | Anti-Bovine IL5 monoclonal antibody | Bovine |
| GM-Tg-equg-T78585-Ab-1/ GM-Tg-equg-T78585-Ab-2 | Anti-Equine IL5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T78585-Ab-1/ GM-Tg-hg-T78585-Ab-2; GM-Tg-rg-T78585-Ab-1/ GM-Tg-rg-T78585-Ab-2; GM-Tg-mg-T78585-Ab-1/ GM-Tg-mg-T78585-Ab-2; GM-Tg-cynog-T78585-Ab-1/ GM-Tg-cynog-T78585-Ab-2; GM-Tg-felg-T78585-Ab-1/ GM-Tg-felg-T78585-Ab-2; GM-Tg-cang-T78585-Ab-1/ GM-Tg-cang-T78585-Ab-2; GM-Tg-bovg-T78585-Ab-1/ GM-Tg-bovg-T78585-Ab-2; GM-Tg-equg-T78585-Ab-1/ GM-Tg-equg-T78585-Ab-2 |
| Products Name | Anti-IL5 monoclonal antibody |
| Format | mab |
| Target Name | IL5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-479 | Pre-Made Reslizumab biosimilar, Whole mAb, Anti-IL5 Antibody: Anti-EDF/IL-5/TRF therapeutic antibody |
| Biosimilar | GMP-Bios-ab-142 | Pre-Made Depemokimab biosimilar, Whole mAb, Anti-IL5 Antibody: Anti-EDF/IL-5/TRF therapeutic antibody |
| Biosimilar | GMP-Bios-ab-341 | Pre-Made Mepolizumab biosimilar, Whole mAb, Anti-IL5 Antibody: Anti-EDF/IL-5/TRF therapeutic antibody |
| Target Antigen | GM-Tg-g-T78585-Ag-1 | Recombinant multi-species IL5/ EDF/ IL-5 protein |
| ORF Viral Vector | vGMLP004769 | human IL5 Lentivirus particle |
| ORF Viral Vector | pGMLP004769 | human IL5 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000260 | mouse Il5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000260 | mouse Il5 Lentivirus particle |
Target information
| Target ID | GM-T78585 |
| Target Name | IL5 |
| Gene ID | 3567,16191,24497,710622,403790,493803,280825,100034199 |
| Gene Symbol and Synonyms | EDF,IL-5,IL5,TRF |
| Uniprot Accession | P05113,Q08125,P48093,Q95J76,O77515,P52173,O02699 |
| Uniprot Entry Name | IL5_HUMAN,IL5_MACMU,IL5_RAT,IL5_FELCA,IL5_CANLF,IL5_BOVIN,IL5_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Hodgkin's disease, Overactive bladder |
| Gene Ensembl | ENSG00000113525 |
| Target Classification | N/A |
The target: IL5, gene name: IL5, also named as EDF, IL-5, TRF. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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