Anti-IR1 monoclonal antibody
Pre-made anti-IR1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T78943-Ab-1/ GM-Tg-hg-T78943-Ab-2 | Anti-Human IR1/NISCH monoclonal antibody | Human |
GM-Tg-rg-T78943-Ab-1/ GM-Tg-rg-T78943-Ab-2 | Anti-Rat IR1/NISCH monoclonal antibody | Rat |
GM-Tg-mg-T78943-Ab-1/ GM-Tg-mg-T78943-Ab-2 | Anti-Mouse IR1/NISCH monoclonal antibody | Mouse |
GM-Tg-cynog-T78943-Ab-1/ GM-Tg-cynog-T78943-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IR1/NISCH monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T78943-Ab-1/ GM-Tg-felg-T78943-Ab-2 | Anti-Feline IR1/NISCH monoclonal antibody | Feline |
GM-Tg-cang-T78943-Ab-1/ GM-Tg-cang-T78943-Ab-2 | Anti-Canine IR1/NISCH monoclonal antibody | Canine |
GM-Tg-bovg-T78943-Ab-1/ GM-Tg-bovg-T78943-Ab-2 | Anti-Bovine IR1/NISCH monoclonal antibody | Bovine |
GM-Tg-equg-T78943-Ab-1/ GM-Tg-equg-T78943-Ab-2 | Anti-Equine IR1/NISCH monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T78943-Ab-1/ GM-Tg-hg-T78943-Ab-2; GM-Tg-rg-T78943-Ab-1/ GM-Tg-rg-T78943-Ab-2; GM-Tg-mg-T78943-Ab-1/ GM-Tg-mg-T78943-Ab-2; GM-Tg-cynog-T78943-Ab-1/ GM-Tg-cynog-T78943-Ab-2; GM-Tg-felg-T78943-Ab-1/ GM-Tg-felg-T78943-Ab-2; GM-Tg-cang-T78943-Ab-1/ GM-Tg-cang-T78943-Ab-2; GM-Tg-bovg-T78943-Ab-1/ GM-Tg-bovg-T78943-Ab-2; GM-Tg-equg-T78943-Ab-1/ GM-Tg-equg-T78943-Ab-2 |
Products Name | Anti-IR1/NISCH monoclonal antibody |
Format | mab |
Target Name | IR1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-IR1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T78943-Ag-1 | Recombinant multi-species NISCH/ IR1/ I-1 protein |
Target information
Target ID | GM-T78943 |
Target Name | IR1 |
Gene ID | 11188,64652,306255,696916,100855697,101083249,100336473,100060179 |
Gene Symbol and Synonyms | 1200007D05Rik,3202002H23Rik,edsn,hIRAS,I-1,I1R,IR1,IRAS,NISCH |
Uniprot Accession | Q9Y2I1,Q4G017 |
Uniprot Entry Name | NISCH_HUMAN,NISCH_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000010322 |
Target Classification | N/A |
The target: IR1, gene name: NISCH, also named as I-1, IR1, IRAS, hIRAS. This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.