Anti-LSHR/ LHCGR/ HHG monoclonal antibody
Anti-LSHR/ LHCGR/ HHG antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T79473-Ab-1/ GM-Tg-hg-T79473-Ab-2 | Anti-Human LHCGR monoclonal antibody | Human |
GM-Tg-rg-T79473-Ab-1/ GM-Tg-rg-T79473-Ab-2 | Anti-Rat LHCGR monoclonal antibody | Rat |
GM-Tg-mg-T79473-Ab-1/ GM-Tg-mg-T79473-Ab-2 | Anti-Mouse LHCGR monoclonal antibody | Mouse |
GM-Tg-cynog-T79473-Ab-1/ GM-Tg-cynog-T79473-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LHCGR monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T79473-Ab-1/ GM-Tg-felg-T79473-Ab-2 | Anti-Feline LHCGR monoclonal antibody | Feline |
GM-Tg-cang-T79473-Ab-1/ GM-Tg-cang-T79473-Ab-2 | Anti-Canine LHCGR monoclonal antibody | Canine |
GM-Tg-bovg-T79473-Ab-1/ GM-Tg-bovg-T79473-Ab-2 | Anti-Bovine LHCGR monoclonal antibody | Bovine |
GM-Tg-equg-T79473-Ab-1/ GM-Tg-equg-T79473-Ab-2 | Anti-Equine LHCGR monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T79473-Ab-1/ GM-Tg-hg-T79473-Ab-2; GM-Tg-rg-T79473-Ab-1/ GM-Tg-rg-T79473-Ab-2; GM-Tg-mg-T79473-Ab-1/ GM-Tg-mg-T79473-Ab-2; GM-Tg-cynog-T79473-Ab-1/ GM-Tg-cynog-T79473-Ab-2; GM-Tg-felg-T79473-Ab-1/ GM-Tg-felg-T79473-Ab-2; GM-Tg-cang-T79473-Ab-1/ GM-Tg-cang-T79473-Ab-2; GM-Tg-bovg-T79473-Ab-1/ GM-Tg-bovg-T79473-Ab-2; GM-Tg-equg-T79473-Ab-1/ GM-Tg-equg-T79473-Ab-2 |
Products Name | Anti-LHCGR monoclonal antibody |
Format | mab |
Target Name | LHCGR |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-LHCGR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-778 | Pre-Made Choriogonadotropin Beta Biosimilar, Recombinant Protein targeting LHCGR: Recombinant therapeutic protein targeting HHG/LCGR/LGR2/LH/CG-R/LH/CGR/LHR/LHRHR/LSH-R/ULG5 |
Target Antigen | Products Developing | Multi-species LSHR/ LHCGR/ HHG VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T79473 |
Target Name | LHCGR |
Gene ID | 3973,16867,25477,715999,481365,101088154,281900,100034043 |
Gene Symbol and Synonyms | Gpcr19-rs1,HHG,LCGR,LGR2,LH-R,LH/CG-R,LH/CGR,LHCGR,LHR,LHRHR,LSH-R,LSHR,ULG5 |
Uniprot Accession | P22888,P16235,Q28005 |
Uniprot Entry Name | LSHR_HUMAN,LSHR_RAT,LSHR_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000138039 |
Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: LHCGR, gene name: LHCGR, also named as HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5. This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.