Anti-PIK3CA monoclonal antibody

Pre-made anti-PIK3CA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PIK3CA/PIK3CA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T80276-Ab-1/ GM-Tg-hg-T80276-Ab-2Anti-Human PIK3CA monoclonal antibodyHuman
GM-Tg-rg-T80276-Ab-1/ GM-Tg-rg-T80276-Ab-2Anti-Rat PIK3CA monoclonal antibodyRat
GM-Tg-mg-T80276-Ab-1/ GM-Tg-mg-T80276-Ab-2Anti-Mouse PIK3CA monoclonal antibodyMouse
GM-Tg-cynog-T80276-Ab-1/ GM-Tg-cynog-T80276-Ab-2Anti-Cynomolgus/ Rhesus macaque PIK3CA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T80276-Ab-1/ GM-Tg-felg-T80276-Ab-2Anti-Feline PIK3CA monoclonal antibodyFeline
GM-Tg-cang-T80276-Ab-1/ GM-Tg-cang-T80276-Ab-2Anti-Canine PIK3CA monoclonal antibodyCanine
GM-Tg-bovg-T80276-Ab-1/ GM-Tg-bovg-T80276-Ab-2Anti-Bovine PIK3CA monoclonal antibodyBovine
GM-Tg-equg-T80276-Ab-1/ GM-Tg-equg-T80276-Ab-2Anti-Equine PIK3CA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T80276-Ab-1/ GM-Tg-hg-T80276-Ab-2; GM-Tg-rg-T80276-Ab-1/ GM-Tg-rg-T80276-Ab-2;
GM-Tg-mg-T80276-Ab-1/ GM-Tg-mg-T80276-Ab-2; GM-Tg-cynog-T80276-Ab-1/ GM-Tg-cynog-T80276-Ab-2;
GM-Tg-felg-T80276-Ab-1/ GM-Tg-felg-T80276-Ab-2; GM-Tg-cang-T80276-Ab-1/ GM-Tg-cang-T80276-Ab-2;
GM-Tg-bovg-T80276-Ab-1/ GM-Tg-bovg-T80276-Ab-2; GM-Tg-equg-T80276-Ab-1/ GM-Tg-equg-T80276-Ab-2
Products NameAnti-PIK3CA monoclonal antibody
Formatmab
Target NamePIK3CA
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PIK3CA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T80276-Ag-1Recombinant multi-species PK3CA/ PIK3CA/ CLAPO protein


    Target information

    Target IDGM-T80276
    Target NamePIK3CA
    Gene ID5290,18706,170911,709959,488084,101097413,282306,100058141
    Gene Symbol and Synonyms6330412C24Rik,caPI3K,CCM4,CLAPO,CLOVE,CWS5,MCAP,MCM,MCMTC,p110,p110-alpha,p110alpha,PI3K,PI3K-alpha,PIK3CA
    Uniprot AccessionP42336,A0A0G2K344,P32871
    Uniprot Entry NamePK3CA_HUMAN,PK3CA_RAT,PK3CA_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseNon-Small Cell Lung Cancer
    Gene EnsemblENSG00000121879
    Target ClassificationKinase

    The target: PIK3CA, gene name: PIK3CA, also named as CLAPO, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.