Anti-GBRB2/ GABRB2/ ICEE2 monoclonal antibody

Anti-GBRB2/ GABRB2/ ICEE2 antibody for FACS & in-vivo assay

Target products collectionGo to GABRB2/GABRB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T80387-Ab-1/ GM-Tg-hg-T80387-Ab-2Anti-Human GABRB2 monoclonal antibodyHuman
GM-Tg-rg-T80387-Ab-1/ GM-Tg-rg-T80387-Ab-2Anti-Rat GABRB2 monoclonal antibodyRat
GM-Tg-mg-T80387-Ab-1/ GM-Tg-mg-T80387-Ab-2Anti-Mouse GABRB2 monoclonal antibodyMouse
GM-Tg-cynog-T80387-Ab-1/ GM-Tg-cynog-T80387-Ab-2Anti-Cynomolgus/ Rhesus macaque GABRB2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T80387-Ab-1/ GM-Tg-felg-T80387-Ab-2Anti-Feline GABRB2 monoclonal antibodyFeline
GM-Tg-cang-T80387-Ab-1/ GM-Tg-cang-T80387-Ab-2Anti-Canine GABRB2 monoclonal antibodyCanine
GM-Tg-bovg-T80387-Ab-1/ GM-Tg-bovg-T80387-Ab-2Anti-Bovine GABRB2 monoclonal antibodyBovine
GM-Tg-equg-T80387-Ab-1/ GM-Tg-equg-T80387-Ab-2Anti-Equine GABRB2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T80387-Ab-1/ GM-Tg-hg-T80387-Ab-2; GM-Tg-rg-T80387-Ab-1/ GM-Tg-rg-T80387-Ab-2;
GM-Tg-mg-T80387-Ab-1/ GM-Tg-mg-T80387-Ab-2; GM-Tg-cynog-T80387-Ab-1/ GM-Tg-cynog-T80387-Ab-2;
GM-Tg-felg-T80387-Ab-1/ GM-Tg-felg-T80387-Ab-2; GM-Tg-cang-T80387-Ab-1/ GM-Tg-cang-T80387-Ab-2;
GM-Tg-bovg-T80387-Ab-1/ GM-Tg-bovg-T80387-Ab-2; GM-Tg-equg-T80387-Ab-1/ GM-Tg-equg-T80387-Ab-2
Products NameAnti-GABRB2 monoclonal antibody
Formatmab
Target NameGABRB2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GABRB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GBRB2/ GABRB2/ ICEE2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T80387
    Target NameGABRB2
    Gene ID2561,14401,25451,696767,101094237,540657,100059608
    Gene Symbol and SynonymsC030002O17Rik,C030021G16Rik,DEE92,Gabrab2,Gabrb-2,GABRB2,GARB2,ICEE2
    Uniprot AccessionP47870,P63138,D1LYT2,P0C2W5
    Uniprot Entry NameGBRB2_HUMAN,GBRB2_MACMU,GBRB2_RAT,GBRB2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000145864
    Target ClassificationN/A

    The target: GABRB2, gene name: GABRB2, also named as ICEE2. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.