Anti-ACE/ ACE1/ CD143 monoclonal antibody

Anti-ACE/ ACE1/ CD143 antibody for FACS & in-vivo assay

Target products collectionGo to ACE/ACE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T82577-Ab-1/ GM-Tg-hg-T82577-Ab-2Anti-Human ACE monoclonal antibodyHuman
GM-Tg-rg-T82577-Ab-1/ GM-Tg-rg-T82577-Ab-2Anti-Rat ACE monoclonal antibodyRat
GM-Tg-mg-T82577-Ab-1/ GM-Tg-mg-T82577-Ab-2Anti-Mouse ACE monoclonal antibodyMouse
GM-Tg-cynog-T82577-Ab-1/ GM-Tg-cynog-T82577-Ab-2Anti-Cynomolgus/ Rhesus macaque ACE monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T82577-Ab-1/ GM-Tg-felg-T82577-Ab-2Anti-Feline ACE monoclonal antibodyFeline
GM-Tg-cang-T82577-Ab-1/ GM-Tg-cang-T82577-Ab-2Anti-Canine ACE monoclonal antibodyCanine
GM-Tg-bovg-T82577-Ab-1/ GM-Tg-bovg-T82577-Ab-2Anti-Bovine ACE monoclonal antibodyBovine
GM-Tg-equg-T82577-Ab-1/ GM-Tg-equg-T82577-Ab-2Anti-Equine ACE monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T82577-Ab-1/ GM-Tg-hg-T82577-Ab-2; GM-Tg-rg-T82577-Ab-1/ GM-Tg-rg-T82577-Ab-2;
GM-Tg-mg-T82577-Ab-1/ GM-Tg-mg-T82577-Ab-2; GM-Tg-cynog-T82577-Ab-1/ GM-Tg-cynog-T82577-Ab-2;
GM-Tg-felg-T82577-Ab-1/ GM-Tg-felg-T82577-Ab-2; GM-Tg-cang-T82577-Ab-1/ GM-Tg-cang-T82577-Ab-2;
GM-Tg-bovg-T82577-Ab-1/ GM-Tg-bovg-T82577-Ab-2; GM-Tg-equg-T82577-Ab-1/ GM-Tg-equg-T82577-Ab-2
Products NameAnti-ACE monoclonal antibody
Target NameACE
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-ACE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACE/ ACE1/ CD143 VLP (virus-like particle) (Products Developing)

    Target information

    Target IDGM-T82577
    Target NameACE
    Gene ID1636,11421,24310,100428661,509484,100064801
    Gene Symbol and SynonymsACE,ACE1,CD143,DCP,DCP1,StsRR92
    Uniprot AccessionP12821,P47820
    Uniprot Entry NameACE_HUMAN,ACE_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    Diseasecardiovascular disease, Dent disease, Schizophrenia, Diffuse lung diseases, cardiorespiratory adaptation, Atopic disease
    Gene EnsemblENSG00000159640
    Target ClassificationN/A

    The target: ACE, gene name: ACE, also named as ACE1, CD143, DCP, DCP1. This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.