Anti-KLKB1/ KLK3/ PKK monoclonal antibody
Anti-KLKB1/ KLK3/ PKK antibody for FACS & in-vivo assay
Go to KLKB1/KLKB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T82739-Ab-1/ GM-Tg-hg-T82739-Ab-2 | Anti-Human KLKB1 monoclonal antibody | Human |
GM-Tg-rg-T82739-Ab-1/ GM-Tg-rg-T82739-Ab-2 | Anti-Rat KLKB1 monoclonal antibody | Rat |
GM-Tg-mg-T82739-Ab-1/ GM-Tg-mg-T82739-Ab-2 | Anti-Mouse KLKB1 monoclonal antibody | Mouse |
GM-Tg-cynog-T82739-Ab-1/ GM-Tg-cynog-T82739-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KLKB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T82739-Ab-1/ GM-Tg-felg-T82739-Ab-2 | Anti-Feline KLKB1 monoclonal antibody | Feline |
GM-Tg-cang-T82739-Ab-1/ GM-Tg-cang-T82739-Ab-2 | Anti-Canine KLKB1 monoclonal antibody | Canine |
GM-Tg-bovg-T82739-Ab-1/ GM-Tg-bovg-T82739-Ab-2 | Anti-Bovine KLKB1 monoclonal antibody | Bovine |
GM-Tg-equg-T82739-Ab-1/ GM-Tg-equg-T82739-Ab-2 | Anti-Equine KLKB1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T82739-Ab-1/ GM-Tg-hg-T82739-Ab-2; GM-Tg-rg-T82739-Ab-1/ GM-Tg-rg-T82739-Ab-2; GM-Tg-mg-T82739-Ab-1/ GM-Tg-mg-T82739-Ab-2; GM-Tg-cynog-T82739-Ab-1/ GM-Tg-cynog-T82739-Ab-2; GM-Tg-felg-T82739-Ab-1/ GM-Tg-felg-T82739-Ab-2; GM-Tg-cang-T82739-Ab-1/ GM-Tg-cang-T82739-Ab-2; GM-Tg-bovg-T82739-Ab-1/ GM-Tg-bovg-T82739-Ab-2; GM-Tg-equg-T82739-Ab-1/ GM-Tg-equg-T82739-Ab-2 |
Products Name | Anti-KLKB1 monoclonal antibody |
Format | mab |
Target Name | KLKB1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-KLKB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-ab-294 | Pre-Made Lanadelumab biosimilar, Whole mAb, Anti-KLKB1 Antibody: Anti-KLK3/PKK/PKKD/PPK therapeutic antibody |
Target Antigen | Products Developing | Multi-species KLKB1/ KLK3/ PKK VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm002691 | mouse Klkb1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002691 | mouse Klkb1 Lentivirus particle |
Target information
Target ID | GM-T82739 |
Target Name | KLKB1 |
Gene ID | 3818,16621,25048,696639,101094092,533547,100056650 |
Gene Symbol and Synonyms | APS,Kal-3,Kal3,Kalp1,KALP15,KLK3,KLKB1,PK,PKK,PKKD,PPK,PSA |
Uniprot Accession | P03952,P14272,Q2KJ63 |
Uniprot Entry Name | KLKB1_HUMAN,KLKB1_RAT,KLKB1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | lung cancer |
Gene Ensembl | ENSG00000164344 |
Target Classification | N/A |
The target: KLKB1, gene name: KLKB1, also named as KLK3, PKK, PKKD, PPK. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.