Anti-FOLR1/ FBP/ FOLR monoclonal antibody

Anti-FOLR1/ FBP/ FOLR antibody for FACS & in-vivo assay

Target products collectionGo to FOLR1/FOLR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83386-Ab-1/ GM-Tg-hg-T83386-Ab-2Anti-Human FOLR1 monoclonal antibodyHuman
GM-Tg-rg-T83386-Ab-1/ GM-Tg-rg-T83386-Ab-2Anti-Rat FOLR1 monoclonal antibodyRat
GM-Tg-mg-T83386-Ab-1/ GM-Tg-mg-T83386-Ab-2Anti-Mouse FOLR1 monoclonal antibodyMouse
GM-Tg-cynog-T83386-Ab-1/ GM-Tg-cynog-T83386-Ab-2Anti-Cynomolgus/ Rhesus macaque FOLR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83386-Ab-1/ GM-Tg-felg-T83386-Ab-2Anti-Feline FOLR1 monoclonal antibodyFeline
GM-Tg-cang-T83386-Ab-1/ GM-Tg-cang-T83386-Ab-2Anti-Canine FOLR1 monoclonal antibodyCanine
GM-Tg-bovg-T83386-Ab-1/ GM-Tg-bovg-T83386-Ab-2Anti-Bovine FOLR1 monoclonal antibodyBovine
GM-Tg-equg-T83386-Ab-1/ GM-Tg-equg-T83386-Ab-2Anti-Equine FOLR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83386-Ab-1/ GM-Tg-hg-T83386-Ab-2; GM-Tg-rg-T83386-Ab-1/ GM-Tg-rg-T83386-Ab-2;
GM-Tg-mg-T83386-Ab-1/ GM-Tg-mg-T83386-Ab-2; GM-Tg-cynog-T83386-Ab-1/ GM-Tg-cynog-T83386-Ab-2;
GM-Tg-felg-T83386-Ab-1/ GM-Tg-felg-T83386-Ab-2; GM-Tg-cang-T83386-Ab-1/ GM-Tg-cang-T83386-Ab-2;
GM-Tg-bovg-T83386-Ab-1/ GM-Tg-bovg-T83386-Ab-2; GM-Tg-equg-T83386-Ab-1/ GM-Tg-equg-T83386-Ab-2
Products NameAnti-FOLR1 monoclonal antibody
Formatmab
Target NameFOLR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FOLR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-850Pre-Made Farletuzumab Ecteribulin Biosimilar, Whole Mab Adc, Anti-Folr1 Antibody: Anti-FBP/FOLR/FRalpha/NCFTD therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-349Pre-Made Mirvetuximab biosimilar, Whole mAb ADC, Anti-FOLR1 Antibody: Anti-FBP/FOLR/FRalpha/NCFTD therapeutic antibody
    BiosimilarGMP-Bios-INN-914Pre-Made Mirvetuximab Soravtansine Biosimilar, Whole Mab Adc, Anti-Folr1 Antibody: Anti-FBP/FOLR/FRalpha/NCFTD therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-205Pre-Made Farletuzumab biosimilar, Whole mAb, Anti-FOLR1 Antibody: Anti-FBP/FOLR/FRalpha/NCFTD therapeutic antibody
    Target AntigenProducts DevelopingMulti-species FOLR1/ FBP/ FOLR VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000860human FOLR1 Lentivirus plasmid
    ORF Viral VectorvGMLP000860human FOLR1 Lentivirus particle
    ORF Viral VectorpGMLPm000941mouse Folr1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000941mouse Folr1 Lentivirus particle


    Target information

    Target IDGM-T83386
    Target NameFOLR1
    Gene ID2348,14275,171049,718388,101084221,539750,100066084
    Gene Symbol and SynonymsFBP,FBP1,Folbp-1,Folbp1,FOLR,FOLR1,FRalpha,NCFTD
    Uniprot AccessionP15328
    Uniprot Entry NameFOLR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseOvary Cancer
    Gene EnsemblENSG00000110195
    Target ClassificationCheckpoint-Immuno Oncology

    The target: FOLR1, gene name: FOLR1, also named as FBP, FOLR. The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.