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Anti-GLCM/ GBA/ GBA1 functional antibody
Anti-GLCM/ GBA/ GBA1 functional antibody for cell culture, ELISA & in-vivo assay
Go to GBA/GBA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T84173-Ab-1/ GM-Tg-hg-T84173-Ab-2 | Anti-Human GBA monoclonal antibody | Human |
| GM-Tg-rg-T84173-Ab-1/ GM-Tg-rg-T84173-Ab-2 | Anti-Rat GBA monoclonal antibody | Rat |
| GM-Tg-mg-T84173-Ab-1/ GM-Tg-mg-T84173-Ab-2 | Anti-Mouse GBA monoclonal antibody | Mouse |
| GM-Tg-cynog-T84173-Ab-1/ GM-Tg-cynog-T84173-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GBA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T84173-Ab-1/ GM-Tg-felg-T84173-Ab-2 | Anti-Feline GBA monoclonal antibody | Feline |
| GM-Tg-cang-T84173-Ab-1/ GM-Tg-cang-T84173-Ab-2 | Anti-Canine GBA monoclonal antibody | Canine |
| GM-Tg-bovg-T84173-Ab-1/ GM-Tg-bovg-T84173-Ab-2 | Anti-Bovine GBA monoclonal antibody | Bovine |
| GM-Tg-equg-T84173-Ab-1/ GM-Tg-equg-T84173-Ab-2 | Anti-Equine GBA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T84173-Ab-1/ GM-Tg-hg-T84173-Ab-2; GM-Tg-rg-T84173-Ab-1/ GM-Tg-rg-T84173-Ab-2; GM-Tg-mg-T84173-Ab-1/ GM-Tg-mg-T84173-Ab-2; GM-Tg-cynog-T84173-Ab-1/ GM-Tg-cynog-T84173-Ab-2; GM-Tg-felg-T84173-Ab-1/ GM-Tg-felg-T84173-Ab-2; GM-Tg-cang-T84173-Ab-1/ GM-Tg-cang-T84173-Ab-2; GM-Tg-bovg-T84173-Ab-1/ GM-Tg-bovg-T84173-Ab-2; GM-Tg-equg-T84173-Ab-1/ GM-Tg-equg-T84173-Ab-2 |
| Products Name | Anti-GBA monoclonal antibody |
| Format | mab |
| Target Name | GBA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GBA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T84173-Ag-1 | Recombinant multi-species GLCM/ GBA/ GBA1 protein |
| ORF Viral Vector | pGMLPm004354 | mouse Gba Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004354 | mouse Gba Lentivirus particle |
Target information
| Target ID | GM-T84173 |
| Target Name | GBA |
| Gene ID | 2629,14466,684536,719103,612206,101091083,537087,100063514 |
| Gene Symbol and Synonyms | betaGC,GBA,GBA1,GC,GCase,GCB,GLUC |
| Uniprot Accession | P04062,Q2KHZ8 |
| Uniprot Entry Name | GLCM_HUMAN,GLCM_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000177628 |
| Target Classification | N/A |
The target: GBA, gene name: GBA, also named as GBA1, GCB, GLUC. This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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