Anti-CD28/ Tp44 monoclonal antibody
Anti-CD28/ Tp44 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T85529-Ab-1/ GM-Tg-hg-T85529-Ab-2 | Anti-Human CD28 monoclonal antibody | Human |
GM-Tg-rg-T85529-Ab-1/ GM-Tg-rg-T85529-Ab-2 | Anti-Rat CD28 monoclonal antibody | Rat |
GM-Tg-mg-T85529-Ab-1/ GM-Tg-mg-T85529-Ab-2 | Anti-Mouse CD28 monoclonal antibody | Mouse |
GM-Tg-cynog-T85529-Ab-1/ GM-Tg-cynog-T85529-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD28 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T85529-Ab-1/ GM-Tg-felg-T85529-Ab-2 | Anti-Feline CD28 monoclonal antibody | Feline |
GM-Tg-cang-T85529-Ab-1/ GM-Tg-cang-T85529-Ab-2 | Anti-Canine CD28 monoclonal antibody | Canine |
GM-Tg-bovg-T85529-Ab-1/ GM-Tg-bovg-T85529-Ab-2 | Anti-Bovine CD28 monoclonal antibody | Bovine |
GM-Tg-equg-T85529-Ab-1/ GM-Tg-equg-T85529-Ab-2 | Anti-Equine CD28 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T85529-Ab-1/ GM-Tg-hg-T85529-Ab-2; GM-Tg-rg-T85529-Ab-1/ GM-Tg-rg-T85529-Ab-2; GM-Tg-mg-T85529-Ab-1/ GM-Tg-mg-T85529-Ab-2; GM-Tg-cynog-T85529-Ab-1/ GM-Tg-cynog-T85529-Ab-2; GM-Tg-felg-T85529-Ab-1/ GM-Tg-felg-T85529-Ab-2; GM-Tg-cang-T85529-Ab-1/ GM-Tg-cang-T85529-Ab-2; GM-Tg-bovg-T85529-Ab-1/ GM-Tg-bovg-T85529-Ab-2; GM-Tg-equg-T85529-Ab-1/ GM-Tg-equg-T85529-Ab-2 |
Products Name | Anti-CD28 monoclonal antibody |
Format | mab |
Target Name | CD28 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CD28 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-ab-326 | Pre-Made Lulizumab biosimilar, Single Domain Variable Fragment;L, Anti-CD28 Antibody: Anti-Tp44 therapeutic antibody |
Biosimilar | GMP-Bios-INN-715 | Pre-Made Acazicolcept Biosimilar, Fusion Protein targeting CD28 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting Tp44 |
Biosimilar | GMP-Bios-INN-901 | |
Target Antigen | Products Developing | Multi-species CD28/ Tp44 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP002973 | human CD28 Lentivirus particle |
ORF Viral Vector | pGMLP002973 | human CD28 Lentivirus plasmid |
ORF Viral Vector | pGMLPm001570 | mouse Cd28 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001570 | mouse Cd28 Lentivirus particle |
Target information
Target ID | GM-T85529 |
Target Name | CD28 |
Gene ID | 940,12487,25660,705313,403646,493802,281050,100067829 |
Gene Symbol and Synonyms | CD28,CD28RNA,Tp44 |
Uniprot Accession | P10747,P31042,O02757,Q28071 |
Uniprot Entry Name | CD28_HUMAN,CD28_RAT,CD28_FELCA,CD28_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000178562 |
Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: CD28, gene name: CD28, also named as Tp44. The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.