Anti-CD28/ Tp44 monoclonal antibody

Anti-CD28/ Tp44 antibody for FACS & in-vivo assay

Target products collectionGo to CD28/CD28 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T85529-Ab-1/ GM-Tg-hg-T85529-Ab-2Anti-Human CD28 monoclonal antibodyHuman
GM-Tg-rg-T85529-Ab-1/ GM-Tg-rg-T85529-Ab-2Anti-Rat CD28 monoclonal antibodyRat
GM-Tg-mg-T85529-Ab-1/ GM-Tg-mg-T85529-Ab-2Anti-Mouse CD28 monoclonal antibodyMouse
GM-Tg-cynog-T85529-Ab-1/ GM-Tg-cynog-T85529-Ab-2Anti-Cynomolgus/ Rhesus macaque CD28 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T85529-Ab-1/ GM-Tg-felg-T85529-Ab-2Anti-Feline CD28 monoclonal antibodyFeline
GM-Tg-cang-T85529-Ab-1/ GM-Tg-cang-T85529-Ab-2Anti-Canine CD28 monoclonal antibodyCanine
GM-Tg-bovg-T85529-Ab-1/ GM-Tg-bovg-T85529-Ab-2Anti-Bovine CD28 monoclonal antibodyBovine
GM-Tg-equg-T85529-Ab-1/ GM-Tg-equg-T85529-Ab-2Anti-Equine CD28 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T85529-Ab-1/ GM-Tg-hg-T85529-Ab-2; GM-Tg-rg-T85529-Ab-1/ GM-Tg-rg-T85529-Ab-2;
GM-Tg-mg-T85529-Ab-1/ GM-Tg-mg-T85529-Ab-2; GM-Tg-cynog-T85529-Ab-1/ GM-Tg-cynog-T85529-Ab-2;
GM-Tg-felg-T85529-Ab-1/ GM-Tg-felg-T85529-Ab-2; GM-Tg-cang-T85529-Ab-1/ GM-Tg-cang-T85529-Ab-2;
GM-Tg-bovg-T85529-Ab-1/ GM-Tg-bovg-T85529-Ab-2; GM-Tg-equg-T85529-Ab-1/ GM-Tg-equg-T85529-Ab-2
Products NameAnti-CD28 monoclonal antibody
Formatmab
Target NameCD28
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD28 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-326Pre-Made Lulizumab biosimilar, Single Domain Variable Fragment;L, Anti-CD28 Antibody: Anti-Tp44 therapeutic antibody
    BiosimilarGMP-Bios-INN-715Pre-Made Acazicolcept Biosimilar, Fusion Protein targeting CD28 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting Tp44
    BiosimilarGMP-Bios-INN-901
    Target AntigenProducts DevelopingMulti-species CD28/ Tp44 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP002973human CD28 Lentivirus particle
    ORF Viral VectorpGMLP002973human CD28 Lentivirus plasmid
    ORF Viral VectorpGMLPm001570mouse Cd28 Lentivirus plasmid
    ORF Viral VectorvGMLPm001570mouse Cd28 Lentivirus particle


    Target information

    Target IDGM-T85529
    Target NameCD28
    Gene ID940,12487,25660,705313,403646,493802,281050,100067829
    Gene Symbol and SynonymsCD28,CD28RNA,Tp44
    Uniprot AccessionP10747,P31042,O02757,Q28071
    Uniprot Entry NameCD28_HUMAN,CD28_RAT,CD28_FELCA,CD28_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000178562
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: CD28, gene name: CD28, also named as Tp44. The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.