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Anti-CDK4 monoclonal antibody
Pre-made anti-CDK4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CDK4/CDK4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85799-Ab-1/ GM-Tg-hg-T85799-Ab-2 | Anti-Human CDK4 monoclonal antibody | Human |
| GM-Tg-rg-T85799-Ab-1/ GM-Tg-rg-T85799-Ab-2 | Anti-Rat CDK4 monoclonal antibody | Rat |
| GM-Tg-mg-T85799-Ab-1/ GM-Tg-mg-T85799-Ab-2 | Anti-Mouse CDK4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T85799-Ab-1/ GM-Tg-cynog-T85799-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDK4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85799-Ab-1/ GM-Tg-felg-T85799-Ab-2 | Anti-Feline CDK4 monoclonal antibody | Feline |
| GM-Tg-cang-T85799-Ab-1/ GM-Tg-cang-T85799-Ab-2 | Anti-Canine CDK4 monoclonal antibody | Canine |
| GM-Tg-bovg-T85799-Ab-1/ GM-Tg-bovg-T85799-Ab-2 | Anti-Bovine CDK4 monoclonal antibody | Bovine |
| GM-Tg-equg-T85799-Ab-1/ GM-Tg-equg-T85799-Ab-2 | Anti-Equine CDK4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85799-Ab-1/ GM-Tg-hg-T85799-Ab-2; GM-Tg-rg-T85799-Ab-1/ GM-Tg-rg-T85799-Ab-2; GM-Tg-mg-T85799-Ab-1/ GM-Tg-mg-T85799-Ab-2; GM-Tg-cynog-T85799-Ab-1/ GM-Tg-cynog-T85799-Ab-2; GM-Tg-felg-T85799-Ab-1/ GM-Tg-felg-T85799-Ab-2; GM-Tg-cang-T85799-Ab-1/ GM-Tg-cang-T85799-Ab-2; GM-Tg-bovg-T85799-Ab-1/ GM-Tg-bovg-T85799-Ab-2; GM-Tg-equg-T85799-Ab-1/ GM-Tg-equg-T85799-Ab-2 |
| Products Name | Anti-CDK4 monoclonal antibody |
| Format | mab |
| Target Name | CDK4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CDK4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T85799-Ag-1 | Recombinant multi-species CDK4/ CMM3/ PSK-J3 protein |
| ORF Viral Vector | vGMAP000163 | Human CDK4 Adenovirus particle |
| ORF Viral Vector | pGMAP000163 | Human CDK4 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001939 | mouse Cdk4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001939 | mouse Cdk4 Lentivirus particle |
Target information
| Target ID | GM-T85799 |
| Target Name | CDK4 |
| Gene ID | 1019,12567,94201,715650,481131,101097903,510618,100051005 |
| Gene Symbol and Synonyms | CDK4,CMM3,Crk3,PSK-J3 |
| Uniprot Accession | P11802,P35426,Q32KY4 |
| Uniprot Entry Name | CDK4_HUMAN,CDK4_RAT,CDK4_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Non-Small Cell Lung Cancer |
| Gene Ensembl | ENSG00000135446 |
| Target Classification | Kinase |
The target: CDK4, gene name: CDK4, also named as CMM3, PSK-J3. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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