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Anti-AA2BR/ ADORA2B/ ADORA2 monoclonal antibody
Anti-AA2BR/ ADORA2B/ ADORA2 antibody for FACS & in-vivo assay
Go to ADORA2B/ADORA2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T86679-Ab-1/ GM-Tg-hg-T86679-Ab-2 | Anti-Human ADORA2B monoclonal antibody | Human |
| GM-Tg-rg-T86679-Ab-1/ GM-Tg-rg-T86679-Ab-2 | Anti-Rat ADORA2B monoclonal antibody | Rat |
| GM-Tg-mg-T86679-Ab-1/ GM-Tg-mg-T86679-Ab-2 | Anti-Mouse ADORA2B monoclonal antibody | Mouse |
| GM-Tg-cynog-T86679-Ab-1/ GM-Tg-cynog-T86679-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADORA2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T86679-Ab-1/ GM-Tg-felg-T86679-Ab-2 | Anti-Feline ADORA2B monoclonal antibody | Feline |
| GM-Tg-cang-T86679-Ab-1/ GM-Tg-cang-T86679-Ab-2 | Anti-Canine ADORA2B monoclonal antibody | Canine |
| GM-Tg-bovg-T86679-Ab-1/ GM-Tg-bovg-T86679-Ab-2 | Anti-Bovine ADORA2B monoclonal antibody | Bovine |
| GM-Tg-equg-T86679-Ab-1/ GM-Tg-equg-T86679-Ab-2 | Anti-Equine ADORA2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T86679-Ab-1/ GM-Tg-hg-T86679-Ab-2; GM-Tg-rg-T86679-Ab-1/ GM-Tg-rg-T86679-Ab-2; GM-Tg-mg-T86679-Ab-1/ GM-Tg-mg-T86679-Ab-2; GM-Tg-cynog-T86679-Ab-1/ GM-Tg-cynog-T86679-Ab-2; GM-Tg-felg-T86679-Ab-1/ GM-Tg-felg-T86679-Ab-2; GM-Tg-cang-T86679-Ab-1/ GM-Tg-cang-T86679-Ab-2; GM-Tg-bovg-T86679-Ab-1/ GM-Tg-bovg-T86679-Ab-2; GM-Tg-equg-T86679-Ab-1/ GM-Tg-equg-T86679-Ab-2 |
| Products Name | Anti-ADORA2B monoclonal antibody |
| Format | mab |
| Target Name | ADORA2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADORA2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AA2BR/ ADORA2B/ ADORA2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002030 | human ADORA2B Lentivirus plasmid |
| ORF Viral Vector | vGMLP002030 | human ADORA2B Lentivirus particle |
| ORF Viral Vector | pGMLPm000330 | mouse Adora2b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000330 | mouse Adora2b Lentivirus particle |
Target information
| Target ID | GM-T86679 |
| Target Name | ADORA2B |
| Gene ID | 136,11541,29316,696848,403410,109494208,529760,100063319 |
| Gene Symbol and Synonyms | A2b,A2BAR,A2BR,AA2BR,ADORA2,ADORA2B,ARA2B |
| Uniprot Accession | P29275,P29276,Q6W3F4,Q1LZD0 |
| Uniprot Entry Name | AA2BR_HUMAN,AA2BR_RAT,AA2BR_CANLF,AA2BR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000170425 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: ADORA2B, gene name: ADORA2B, also named as ADORA2. This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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