Anti-PTAFR/ PAFR monoclonal antibody

Anti-PTAFR/ PAFR antibody for FACS & in-vivo assay

Target products collectionGo to PTAFR/PTAFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T87023-Ab-1/ GM-Tg-hg-T87023-Ab-2Anti-Human PTAFR monoclonal antibodyHuman
GM-Tg-rg-T87023-Ab-1/ GM-Tg-rg-T87023-Ab-2Anti-Rat PTAFR monoclonal antibodyRat
GM-Tg-mg-T87023-Ab-1/ GM-Tg-mg-T87023-Ab-2Anti-Mouse PTAFR monoclonal antibodyMouse
GM-Tg-cynog-T87023-Ab-1/ GM-Tg-cynog-T87023-Ab-2Anti-Cynomolgus/ Rhesus macaque PTAFR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T87023-Ab-1/ GM-Tg-felg-T87023-Ab-2Anti-Feline PTAFR monoclonal antibodyFeline
GM-Tg-cang-T87023-Ab-1/ GM-Tg-cang-T87023-Ab-2Anti-Canine PTAFR monoclonal antibodyCanine
GM-Tg-bovg-T87023-Ab-1/ GM-Tg-bovg-T87023-Ab-2Anti-Bovine PTAFR monoclonal antibodyBovine
GM-Tg-equg-T87023-Ab-1/ GM-Tg-equg-T87023-Ab-2Anti-Equine PTAFR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T87023-Ab-1/ GM-Tg-hg-T87023-Ab-2; GM-Tg-rg-T87023-Ab-1/ GM-Tg-rg-T87023-Ab-2;
GM-Tg-mg-T87023-Ab-1/ GM-Tg-mg-T87023-Ab-2; GM-Tg-cynog-T87023-Ab-1/ GM-Tg-cynog-T87023-Ab-2;
GM-Tg-felg-T87023-Ab-1/ GM-Tg-felg-T87023-Ab-2; GM-Tg-cang-T87023-Ab-1/ GM-Tg-cang-T87023-Ab-2;
GM-Tg-bovg-T87023-Ab-1/ GM-Tg-bovg-T87023-Ab-2; GM-Tg-equg-T87023-Ab-1/ GM-Tg-equg-T87023-Ab-2
Products NameAnti-PTAFR monoclonal antibody
Formatmab
Target NamePTAFR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTAFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PTAFR/ PAFR VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004334human PTAFR Lentivirus particle
    ORF Viral VectorpGMLP004334human PTAFR Lentivirus plasmid
    ORF Viral VectorpGMLPm003536mouse Ptafr Lentivirus plasmid
    ORF Viral VectorpGMLPm004871mouse Ptafr Lentivirus plasmid
    ORF Viral VectorvGMLPm003536mouse Ptafr Lentivirus particle
    ORF Viral VectorvGMLPm004871mouse Ptafr Lentivirus particle


    Target information

    Target IDGM-T87023
    Target NamePTAFR
    Gene ID5724,19204,58949,716788,487336,101085906,518283,106780838
    Gene Symbol and SynonymsPAF-R,PAFR,PTAFR
    Uniprot AccessionP25105,P46002,P35366,Q9TTY5
    Uniprot Entry NamePTAFR_HUMAN,PTAFR_MACMU,PTAFR_RAT,PTAFR_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000169403
    Target ClassificationGPCR

    The target: PTAFR, gene name: PTAFR, also named as PAFR. This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.