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Anti-IMPDH2 monoclonal antibody
Pre-made anti-IMPDH2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IMPDH2/IMPDH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T89360-Ab-1/ GM-Tg-hg-T89360-Ab-2 | Anti-Human IMPDH2 monoclonal antibody | Human |
| GM-Tg-rg-T89360-Ab-1/ GM-Tg-rg-T89360-Ab-2 | Anti-Rat IMPDH2 monoclonal antibody | Rat |
| GM-Tg-mg-T89360-Ab-1/ GM-Tg-mg-T89360-Ab-2 | Anti-Mouse IMPDH2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T89360-Ab-1/ GM-Tg-cynog-T89360-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IMPDH2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T89360-Ab-1/ GM-Tg-felg-T89360-Ab-2 | Anti-Feline IMPDH2 monoclonal antibody | Feline |
| GM-Tg-cang-T89360-Ab-1/ GM-Tg-cang-T89360-Ab-2 | Anti-Canine IMPDH2 monoclonal antibody | Canine |
| GM-Tg-bovg-T89360-Ab-1/ GM-Tg-bovg-T89360-Ab-2 | Anti-Bovine IMPDH2 monoclonal antibody | Bovine |
| GM-Tg-equg-T89360-Ab-1/ GM-Tg-equg-T89360-Ab-2 | Anti-Equine IMPDH2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T89360-Ab-1/ GM-Tg-hg-T89360-Ab-2; GM-Tg-rg-T89360-Ab-1/ GM-Tg-rg-T89360-Ab-2; GM-Tg-mg-T89360-Ab-1/ GM-Tg-mg-T89360-Ab-2; GM-Tg-cynog-T89360-Ab-1/ GM-Tg-cynog-T89360-Ab-2; GM-Tg-felg-T89360-Ab-1/ GM-Tg-felg-T89360-Ab-2; GM-Tg-cang-T89360-Ab-1/ GM-Tg-cang-T89360-Ab-2; GM-Tg-bovg-T89360-Ab-1/ GM-Tg-bovg-T89360-Ab-2; GM-Tg-equg-T89360-Ab-1/ GM-Tg-equg-T89360-Ab-2 |
| Products Name | Anti-IMPDH2 monoclonal antibody |
| Format | mab |
| Target Name | IMPDH2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IMPDH2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T89360-Ag-1 | Recombinant multi-species IMDH2/ IMPDH2/ IMPD2 protein |
| ORF Viral Vector | vGMLP002681 | human IMPDH2 Lentivirus particle |
| ORF Viral Vector | pGMLP002681 | human IMPDH2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005028 | mouse Impdh2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005028 | mouse Impdh2 Lentivirus particle |
Target information
| Target ID | GM-T89360 |
| Target Name | IMPDH2 |
| Gene ID | 3615,23918,301005,708307,476630,101080693,511969,100063255 |
| Gene Symbol and Synonyms | IMPD,IMPD 2,IMPD2,IMPDH 2,IMPDH-II,IMPDH2 |
| Uniprot Accession | P12268,E9PU28,Q3SWY3 |
| Uniprot Entry Name | IMDH2_HUMAN,IMDH2_RAT,IMDH2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000178035 |
| Target Classification | N/A |
The target: IMPDH2, gene name: IMPDH2, also named as IMPD2, IMPDH-II. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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