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Anti-IL5RA/ CD125/ CDw125 monoclonal antibody
Anti-IL5RA/ CD125/ CDw125 antibody for FACS & in-vivo assay
Go to IL5RA/IL5RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T90828-Ab-1/ GM-Tg-hg-T90828-Ab-2 | Anti-Human IL5RA monoclonal antibody | Human |
| GM-Tg-rg-T90828-Ab-1/ GM-Tg-rg-T90828-Ab-2 | Anti-Rat IL5RA monoclonal antibody | Rat |
| GM-Tg-mg-T90828-Ab-1/ GM-Tg-mg-T90828-Ab-2 | Anti-Mouse IL5RA monoclonal antibody | Mouse |
| GM-Tg-cynog-T90828-Ab-1/ GM-Tg-cynog-T90828-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL5RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T90828-Ab-1/ GM-Tg-felg-T90828-Ab-2 | Anti-Feline IL5RA monoclonal antibody | Feline |
| GM-Tg-cang-T90828-Ab-1/ GM-Tg-cang-T90828-Ab-2 | Anti-Canine IL5RA monoclonal antibody | Canine |
| GM-Tg-bovg-T90828-Ab-1/ GM-Tg-bovg-T90828-Ab-2 | Anti-Bovine IL5RA monoclonal antibody | Bovine |
| GM-Tg-equg-T90828-Ab-1/ GM-Tg-equg-T90828-Ab-2 | Anti-Equine IL5RA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T90828-Ab-1/ GM-Tg-hg-T90828-Ab-2; GM-Tg-rg-T90828-Ab-1/ GM-Tg-rg-T90828-Ab-2; GM-Tg-mg-T90828-Ab-1/ GM-Tg-mg-T90828-Ab-2; GM-Tg-cynog-T90828-Ab-1/ GM-Tg-cynog-T90828-Ab-2; GM-Tg-felg-T90828-Ab-1/ GM-Tg-felg-T90828-Ab-2; GM-Tg-cang-T90828-Ab-1/ GM-Tg-cang-T90828-Ab-2; GM-Tg-bovg-T90828-Ab-1/ GM-Tg-bovg-T90828-Ab-2; GM-Tg-equg-T90828-Ab-1/ GM-Tg-equg-T90828-Ab-2 |
| Products Name | Anti-IL5RA monoclonal antibody |
| Format | mab |
| Target Name | IL5RA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL5RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-058 | Pre-Made Benralizumab biosimilar, Whole mAb, Anti-IL5RA Antibody: Anti-CD125/CDw125/HSIL5R3/IL5R therapeutic antibody |
| Target Antigen | Products Developing | Multi-species IL5RA/ CD125/ CDw125 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001668 | human IL5RA Lentivirus plasmid |
| ORF Viral Vector | vGMLP001668 | human IL5RA Lentivirus particle |
| ORF Viral Vector | pGMLPm004308 | mouse Il5ra Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004308 | mouse Il5ra Lentivirus particle |
Target information
| Target ID | GM-T90828 |
| Target Name | IL5RA |
| Gene ID | 3568,16192,114103,704649,476553,101099031,615848,100060212 |
| Gene Symbol and Synonyms | CD125,CDw125,HSIL5R3,IL5R,IL5RA |
| Uniprot Accession | Q01344 |
| Uniprot Entry Name | IL5RA_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000091181 |
| Target Classification | N/A |
The target: IL5RA, gene name: IL5RA, also named as CD125, CDw125, HSIL5R3, IL5R. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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