Anti-IL5RA/ CD125/ CDw125 antibody for FACS & in-vivo assay| GMab

Pre-made anti-IL5RA benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IL5RA mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

The target: IL5RA, gene name: IL5RA, also named as CD125, CDw125, HSIL5R3, IL5R. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].

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Catalog No.	List Price (In USD)	Discount Price (In USD)	Qty (Quantity)	Sum (In USD)
GM-Tg-hg-T90828-Ab-1-1mg	5150	3090
GM-Tg-hg-T90828-Ab-1-10mg	Inquiry	Inquiry
GM-Tg-hg-T90828-Ab-1-100mg	Inquiry	Inquiry
GM-Tg-hg-T90828-Ab-2-1mg	5150	3090
GM-Tg-hg-T90828-Ab-2-10mg	Inquiry	Inquiry
GM-Tg-hg-T90828-Ab-2-100mg	Inquiry	Inquiry
GM-Tg-hg-T90828-Ab-xmg	Inquiry	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Catalog No.	GM-Tg-hg-T90828-Ab-1, GM-Tg-hg-T90828-Ab-2
Products Name	Anti-IL5RA monoclonal antibody
Format	mab
Target Name	IL5RA
Gene ID	IL5RA
Gene Name	IL5RA
Gene Alias	CD125, CDw125, HSIL5R3, IL5R
Protein Sub-location	Transmembrane Protein
Category of antibody	FACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)	Mouse
Species Reactivity	Human(H)
CH1+2+3 Isotype (Receptor identification)	IgG
Type of Light Chain (VD-LC)	N/A
Expression platform	Mammalian Expression
Bioactivity validation	Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Tag	Fc
Products description	Pre-made anti-IL5RA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity	Purity: ≥95% (SDS-PAGE)
Application	Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.