Anti-ITK monoclonal antibody

Pre-made anti-ITK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to ITK/ITK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T91761-Ab-1/ GM-Tg-hg-T91761-Ab-2Anti-Human ITK monoclonal antibodyHuman
GM-Tg-rg-T91761-Ab-1/ GM-Tg-rg-T91761-Ab-2Anti-Rat ITK monoclonal antibodyRat
GM-Tg-mg-T91761-Ab-1/ GM-Tg-mg-T91761-Ab-2Anti-Mouse ITK monoclonal antibodyMouse
GM-Tg-cynog-T91761-Ab-1/ GM-Tg-cynog-T91761-Ab-2Anti-Cynomolgus/ Rhesus macaque ITK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T91761-Ab-1/ GM-Tg-felg-T91761-Ab-2Anti-Feline ITK monoclonal antibodyFeline
GM-Tg-cang-T91761-Ab-1/ GM-Tg-cang-T91761-Ab-2Anti-Canine ITK monoclonal antibodyCanine
GM-Tg-bovg-T91761-Ab-1/ GM-Tg-bovg-T91761-Ab-2Anti-Bovine ITK monoclonal antibodyBovine
GM-Tg-equg-T91761-Ab-1/ GM-Tg-equg-T91761-Ab-2Anti-Equine ITK monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T91761-Ab-1/ GM-Tg-hg-T91761-Ab-2; GM-Tg-rg-T91761-Ab-1/ GM-Tg-rg-T91761-Ab-2;
GM-Tg-mg-T91761-Ab-1/ GM-Tg-mg-T91761-Ab-2; GM-Tg-cynog-T91761-Ab-1/ GM-Tg-cynog-T91761-Ab-2;
GM-Tg-felg-T91761-Ab-1/ GM-Tg-felg-T91761-Ab-2; GM-Tg-cang-T91761-Ab-1/ GM-Tg-cang-T91761-Ab-2;
GM-Tg-bovg-T91761-Ab-1/ GM-Tg-bovg-T91761-Ab-2; GM-Tg-equg-T91761-Ab-1/ GM-Tg-equg-T91761-Ab-2
Products NameAnti-ITK monoclonal antibody
Formatmab
Target NameITK
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-ITK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T91761-Ag-1Recombinant multi-species ITK/ EMT/ LPFS1 protein


    Target information

    Target IDGM-T91761
    Target NameITK
    Gene ID3702,16428,363577,715471,489159,101100785,522311,100071232
    Gene Symbol and SynonymsEMT,ITK,LPFS1,LYK,PSCTK2,Tcsk,Tsk
    Uniprot AccessionQ08881
    Uniprot Entry NameITK_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000113263
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: ITK, gene name: ITK, also named as EMT, LPFS1, LYK, PSCTK2. This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.