Anti-TIE2/ TEK/ CD202B monoclonal antibody

Anti-TIE2/ TEK/ CD202B antibody for FACS & in-vivo assay

Target products collectionGo to TEK/TEK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T92144-Ab-1/ GM-Tg-hg-T92144-Ab-2Anti-Human TEK monoclonal antibodyHuman
GM-Tg-rg-T92144-Ab-1/ GM-Tg-rg-T92144-Ab-2Anti-Rat TEK monoclonal antibodyRat
GM-Tg-mg-T92144-Ab-1/ GM-Tg-mg-T92144-Ab-2Anti-Mouse TEK monoclonal antibodyMouse
GM-Tg-cynog-T92144-Ab-1/ GM-Tg-cynog-T92144-Ab-2Anti-Cynomolgus/ Rhesus macaque TEK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T92144-Ab-1/ GM-Tg-felg-T92144-Ab-2Anti-Feline TEK monoclonal antibodyFeline
GM-Tg-cang-T92144-Ab-1/ GM-Tg-cang-T92144-Ab-2Anti-Canine TEK monoclonal antibodyCanine
GM-Tg-bovg-T92144-Ab-1/ GM-Tg-bovg-T92144-Ab-2Anti-Bovine TEK monoclonal antibodyBovine
GM-Tg-equg-T92144-Ab-1/ GM-Tg-equg-T92144-Ab-2Anti-Equine TEK monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T92144-Ab-1/ GM-Tg-hg-T92144-Ab-2; GM-Tg-rg-T92144-Ab-1/ GM-Tg-rg-T92144-Ab-2;
GM-Tg-mg-T92144-Ab-1/ GM-Tg-mg-T92144-Ab-2; GM-Tg-cynog-T92144-Ab-1/ GM-Tg-cynog-T92144-Ab-2;
GM-Tg-felg-T92144-Ab-1/ GM-Tg-felg-T92144-Ab-2; GM-Tg-cang-T92144-Ab-1/ GM-Tg-cang-T92144-Ab-2;
GM-Tg-bovg-T92144-Ab-1/ GM-Tg-bovg-T92144-Ab-2; GM-Tg-equg-T92144-Ab-1/ GM-Tg-equg-T92144-Ab-2
Products NameAnti-TEK monoclonal antibody
Target NameTEK
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-TEK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TIE2/ TEK/ CD202B VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP005155human TEK Lentivirus particle
    ORF Viral VectorpGMLP005155human TEK Lentivirus plasmid

    Target information

    Target IDGM-T92144
    Target NameTEK
    Gene ID7010,21687,89804,707455,403714,101091977,280939,100066963
    Gene Symbol and SynonymsCD202B,GLC3E,Hyk,STK1,TEK,TIE-2,TIE2,VMCM,VMCM1
    Uniprot AccessionQ02763,Q06807
    Uniprot Entry NameTIE2_HUMAN,TIE2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000120156
    Target ClassificationKinase

    The target: TEK, gene name: TEK, also named as CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.