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Anti-TIE2/ TEK/ CD202B monoclonal antibody
Anti-TIE2/ TEK/ CD202B antibody for FACS & in-vivo assay
Go to TEK/TEK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92144-Ab-1/ GM-Tg-hg-T92144-Ab-2 | Anti-Human TEK monoclonal antibody | Human |
| GM-Tg-rg-T92144-Ab-1/ GM-Tg-rg-T92144-Ab-2 | Anti-Rat TEK monoclonal antibody | Rat |
| GM-Tg-mg-T92144-Ab-1/ GM-Tg-mg-T92144-Ab-2 | Anti-Mouse TEK monoclonal antibody | Mouse |
| GM-Tg-cynog-T92144-Ab-1/ GM-Tg-cynog-T92144-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TEK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92144-Ab-1/ GM-Tg-felg-T92144-Ab-2 | Anti-Feline TEK monoclonal antibody | Feline |
| GM-Tg-cang-T92144-Ab-1/ GM-Tg-cang-T92144-Ab-2 | Anti-Canine TEK monoclonal antibody | Canine |
| GM-Tg-bovg-T92144-Ab-1/ GM-Tg-bovg-T92144-Ab-2 | Anti-Bovine TEK monoclonal antibody | Bovine |
| GM-Tg-equg-T92144-Ab-1/ GM-Tg-equg-T92144-Ab-2 | Anti-Equine TEK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92144-Ab-1/ GM-Tg-hg-T92144-Ab-2; GM-Tg-rg-T92144-Ab-1/ GM-Tg-rg-T92144-Ab-2; GM-Tg-mg-T92144-Ab-1/ GM-Tg-mg-T92144-Ab-2; GM-Tg-cynog-T92144-Ab-1/ GM-Tg-cynog-T92144-Ab-2; GM-Tg-felg-T92144-Ab-1/ GM-Tg-felg-T92144-Ab-2; GM-Tg-cang-T92144-Ab-1/ GM-Tg-cang-T92144-Ab-2; GM-Tg-bovg-T92144-Ab-1/ GM-Tg-bovg-T92144-Ab-2; GM-Tg-equg-T92144-Ab-1/ GM-Tg-equg-T92144-Ab-2 |
| Products Name | Anti-TEK monoclonal antibody |
| Format | mab |
| Target Name | TEK |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TEK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TIE2/ TEK/ CD202B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP005155 | human TEK Lentivirus particle |
| ORF Viral Vector | pGMLP005155 | human TEK Lentivirus plasmid |
Target information
| Target ID | GM-T92144 |
| Target Name | TEK |
| Gene ID | 7010,21687,89804,707455,403714,101091977,280939,100066963 |
| Gene Symbol and Synonyms | CD202B,GLC3E,Hyk,STK1,TEK,TIE-2,TIE2,VMCM,VMCM1 |
| Uniprot Accession | Q02763,Q06807 |
| Uniprot Entry Name | TIE2_HUMAN,TIE2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000120156 |
| Target Classification | Kinase |
The target: TEK, gene name: TEK, also named as CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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