Anti-EDNRB/ ABCDS/ ET-B monoclonal antibody

Anti-EDNRB/ ABCDS/ ET-B antibody for FACS & in-vivo assay

Target products collectionGo to EDNRB/EDNRB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T92828-Ab-1/ GM-Tg-hg-T92828-Ab-2Anti-Human EDNRB monoclonal antibodyHuman
GM-Tg-rg-T92828-Ab-1/ GM-Tg-rg-T92828-Ab-2Anti-Rat EDNRB monoclonal antibodyRat
GM-Tg-mg-T92828-Ab-1/ GM-Tg-mg-T92828-Ab-2Anti-Mouse EDNRB monoclonal antibodyMouse
GM-Tg-cynog-T92828-Ab-1/ GM-Tg-cynog-T92828-Ab-2Anti-Cynomolgus/ Rhesus macaque EDNRB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T92828-Ab-1/ GM-Tg-felg-T92828-Ab-2Anti-Feline EDNRB monoclonal antibodyFeline
GM-Tg-cang-T92828-Ab-1/ GM-Tg-cang-T92828-Ab-2Anti-Canine EDNRB monoclonal antibodyCanine
GM-Tg-bovg-T92828-Ab-1/ GM-Tg-bovg-T92828-Ab-2Anti-Bovine EDNRB monoclonal antibodyBovine
GM-Tg-equg-T92828-Ab-1/ GM-Tg-equg-T92828-Ab-2Anti-Equine EDNRB monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T92828-Ab-1/ GM-Tg-hg-T92828-Ab-2; GM-Tg-rg-T92828-Ab-1/ GM-Tg-rg-T92828-Ab-2;
GM-Tg-mg-T92828-Ab-1/ GM-Tg-mg-T92828-Ab-2; GM-Tg-cynog-T92828-Ab-1/ GM-Tg-cynog-T92828-Ab-2;
GM-Tg-felg-T92828-Ab-1/ GM-Tg-felg-T92828-Ab-2; GM-Tg-cang-T92828-Ab-1/ GM-Tg-cang-T92828-Ab-2;
GM-Tg-bovg-T92828-Ab-1/ GM-Tg-bovg-T92828-Ab-2; GM-Tg-equg-T92828-Ab-1/ GM-Tg-equg-T92828-Ab-2
Products NameAnti-EDNRB monoclonal antibody
Formatmab
Target NameEDNRB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EDNRB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species EDNRB/ ABCDS/ ET-B VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAP000428Human EDNRB Adenovirus particle
    ORF Viral VectorpGMAP000428Human EDNRB Adenovirus plasmid
    ORF Viral VectorpGMLPm002558mouse Ednrb Lentivirus plasmid
    ORF Viral VectorvGMLPm002558mouse Ednrb Lentivirus particle


    Target information

    Target IDGM-T92828
    Target NameEDNRB
    Gene ID1910,13618,50672,697329,403862,101086531,281750,100033875
    Gene Symbol and SynonymsABCDS,Ednra,EDNRB,ET-B,ET-BR,ETB,ETB1,ETBR,ETR-b,ETRB,HSCR,HSCR2,Sox10m1,WS4A
    Uniprot AccessionP24530,P21451,P56497,P28088,O62709
    Uniprot Entry NameEDNRB_HUMAN,EDNRB_RAT,EDNRB_CANLF,EDNRB_BOVIN,EDNRB_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000136160
    Target ClassificationGPCR, Tumor-associated antigen (TAA)

    The target: EDNRB, gene name: EDNRB, also named as ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.