Anti-EDNRB/ ABCDS/ ET-B monoclonal antibody
Anti-EDNRB/ ABCDS/ ET-B antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T92828-Ab-1/ GM-Tg-hg-T92828-Ab-2 | Anti-Human EDNRB monoclonal antibody | Human |
GM-Tg-rg-T92828-Ab-1/ GM-Tg-rg-T92828-Ab-2 | Anti-Rat EDNRB monoclonal antibody | Rat |
GM-Tg-mg-T92828-Ab-1/ GM-Tg-mg-T92828-Ab-2 | Anti-Mouse EDNRB monoclonal antibody | Mouse |
GM-Tg-cynog-T92828-Ab-1/ GM-Tg-cynog-T92828-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDNRB monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T92828-Ab-1/ GM-Tg-felg-T92828-Ab-2 | Anti-Feline EDNRB monoclonal antibody | Feline |
GM-Tg-cang-T92828-Ab-1/ GM-Tg-cang-T92828-Ab-2 | Anti-Canine EDNRB monoclonal antibody | Canine |
GM-Tg-bovg-T92828-Ab-1/ GM-Tg-bovg-T92828-Ab-2 | Anti-Bovine EDNRB monoclonal antibody | Bovine |
GM-Tg-equg-T92828-Ab-1/ GM-Tg-equg-T92828-Ab-2 | Anti-Equine EDNRB monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T92828-Ab-1/ GM-Tg-hg-T92828-Ab-2; GM-Tg-rg-T92828-Ab-1/ GM-Tg-rg-T92828-Ab-2; GM-Tg-mg-T92828-Ab-1/ GM-Tg-mg-T92828-Ab-2; GM-Tg-cynog-T92828-Ab-1/ GM-Tg-cynog-T92828-Ab-2; GM-Tg-felg-T92828-Ab-1/ GM-Tg-felg-T92828-Ab-2; GM-Tg-cang-T92828-Ab-1/ GM-Tg-cang-T92828-Ab-2; GM-Tg-bovg-T92828-Ab-1/ GM-Tg-bovg-T92828-Ab-2; GM-Tg-equg-T92828-Ab-1/ GM-Tg-equg-T92828-Ab-2 |
Products Name | Anti-EDNRB monoclonal antibody |
Format | mab |
Target Name | EDNRB |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-EDNRB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species EDNRB/ ABCDS/ ET-B VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMAP000428 | Human EDNRB Adenovirus particle |
ORF Viral Vector | pGMAP000428 | Human EDNRB Adenovirus plasmid |
ORF Viral Vector | pGMLPm002558 | mouse Ednrb Lentivirus plasmid |
ORF Viral Vector | vGMLPm002558 | mouse Ednrb Lentivirus particle |
Target information
Target ID | GM-T92828 |
Target Name | EDNRB |
Gene ID | 1910,13618,50672,697329,403862,101086531,281750,100033875 |
Gene Symbol and Synonyms | ABCDS,Ednra,EDNRB,ET-B,ET-BR,ETB,ETB1,ETBR,ETR-b,ETRB,HSCR,HSCR2,Sox10m1,WS4A |
Uniprot Accession | P24530,P21451,P56497,P28088,O62709 |
Uniprot Entry Name | EDNRB_HUMAN,EDNRB_RAT,EDNRB_CANLF,EDNRB_BOVIN,EDNRB_HORSE |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000136160 |
Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: EDNRB, gene name: EDNRB, also named as ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.