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Anti-GRN/ CLN11/ GEP monoclonal antibody
Anti-GRN/ CLN11/ GEP antibody for FACS & in-vivo assay
Go to GRN/GRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T93830-Ab-1/ GM-Tg-hg-T93830-Ab-2 | Anti-Human GRN monoclonal antibody | Human |
| GM-Tg-rg-T93830-Ab-1/ GM-Tg-rg-T93830-Ab-2 | Anti-Rat GRN monoclonal antibody | Rat |
| GM-Tg-mg-T93830-Ab-1/ GM-Tg-mg-T93830-Ab-2 | Anti-Mouse GRN monoclonal antibody | Mouse |
| GM-Tg-cynog-T93830-Ab-1/ GM-Tg-cynog-T93830-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T93830-Ab-1/ GM-Tg-felg-T93830-Ab-2 | Anti-Feline GRN monoclonal antibody | Feline |
| GM-Tg-cang-T93830-Ab-1/ GM-Tg-cang-T93830-Ab-2 | Anti-Canine GRN monoclonal antibody | Canine |
| GM-Tg-bovg-T93830-Ab-1/ GM-Tg-bovg-T93830-Ab-2 | Anti-Bovine GRN monoclonal antibody | Bovine |
| GM-Tg-equg-T93830-Ab-1/ GM-Tg-equg-T93830-Ab-2 | Anti-Equine GRN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T93830-Ab-1/ GM-Tg-hg-T93830-Ab-2; GM-Tg-rg-T93830-Ab-1/ GM-Tg-rg-T93830-Ab-2; GM-Tg-mg-T93830-Ab-1/ GM-Tg-mg-T93830-Ab-2; GM-Tg-cynog-T93830-Ab-1/ GM-Tg-cynog-T93830-Ab-2; GM-Tg-felg-T93830-Ab-1/ GM-Tg-felg-T93830-Ab-2; GM-Tg-cang-T93830-Ab-1/ GM-Tg-cang-T93830-Ab-2; GM-Tg-bovg-T93830-Ab-1/ GM-Tg-bovg-T93830-Ab-2; GM-Tg-equg-T93830-Ab-1/ GM-Tg-equg-T93830-Ab-2 |
| Products Name | Anti-GRN monoclonal antibody |
| Format | mab |
| Target Name | GRN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRN/ CLN11/ GEP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000509 | Human GRN Adenovirus particle |
| ORF Viral Vector | pGMAP000509 | Human GRN Adenovirus plasmid |
| ORF Viral Vector | vGMLP003819 | human GRN Lentivirus particle |
| ORF Viral Vector | pGMLP003819 | human GRN Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004393 | mouse Grn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004393 | mouse Grn Lentivirus particle |
Target information
| Target ID | GM-T93830 |
| Target Name | GRN |
| Gene ID | 2896,14824,29143,714851,480501,101100680,767942,100051035 |
| Gene Symbol and Synonyms | CLN11,epithelin,GEP,GP88,GRN,PCDGF,PEPI,PGRN |
| Uniprot Accession | P28799,P23785 |
| Uniprot Entry Name | GRN_HUMAN,GRN_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer, Type 1 diabetes mellitus |
| Gene Ensembl | ENSG00000030582 |
| Target Classification | N/A |
The target: GRN, gene name: GRN, also named as CLN11, GEP, GP88, PCDGF, PEPI, PGRN. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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