Anti-THRB/ F2/ PT monoclonal antibody
Anti-THRB/ F2/ PT antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T94033-Ab-1/ GM-Tg-hg-T94033-Ab-2 | Anti-Human F2 monoclonal antibody | Human |
GM-Tg-rg-T94033-Ab-1/ GM-Tg-rg-T94033-Ab-2 | Anti-Rat F2 monoclonal antibody | Rat |
GM-Tg-mg-T94033-Ab-1/ GM-Tg-mg-T94033-Ab-2 | Anti-Mouse F2 monoclonal antibody | Mouse |
GM-Tg-cynog-T94033-Ab-1/ GM-Tg-cynog-T94033-Ab-2 | Anti-Cynomolgus/ Rhesus macaque F2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T94033-Ab-1/ GM-Tg-felg-T94033-Ab-2 | Anti-Feline F2 monoclonal antibody | Feline |
GM-Tg-cang-T94033-Ab-1/ GM-Tg-cang-T94033-Ab-2 | Anti-Canine F2 monoclonal antibody | Canine |
GM-Tg-bovg-T94033-Ab-1/ GM-Tg-bovg-T94033-Ab-2 | Anti-Bovine F2 monoclonal antibody | Bovine |
GM-Tg-equg-T94033-Ab-1/ GM-Tg-equg-T94033-Ab-2 | Anti-Equine F2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T94033-Ab-1/ GM-Tg-hg-T94033-Ab-2; GM-Tg-rg-T94033-Ab-1/ GM-Tg-rg-T94033-Ab-2; GM-Tg-mg-T94033-Ab-1/ GM-Tg-mg-T94033-Ab-2; GM-Tg-cynog-T94033-Ab-1/ GM-Tg-cynog-T94033-Ab-2; GM-Tg-felg-T94033-Ab-1/ GM-Tg-felg-T94033-Ab-2; GM-Tg-cang-T94033-Ab-1/ GM-Tg-cang-T94033-Ab-2; GM-Tg-bovg-T94033-Ab-1/ GM-Tg-bovg-T94033-Ab-2; GM-Tg-equg-T94033-Ab-1/ GM-Tg-equg-T94033-Ab-2 |
Products Name | Anti-F2 monoclonal antibody |
Format | mab |
Target Name | F2 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-F2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species THRB/ F2/ PT VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMAD000655 | house mouse F2 Adenovirus plasmid |
ORF Viral Vector | pGMLPm004996 | mouse F2 Lentivirus plasmid |
ORF Viral Vector | vGMAD000655 | house mouse F2 Adenovirus particle |
ORF Viral Vector | vGMLPm004996 | mouse F2 Lentivirus particle |
Target information
Target ID | GM-T94033 |
Target Name | F2 |
Gene ID | 2147,14061,29251,712729,100856539,101090463,280685,100057521 |
Gene Symbol and Synonyms | Cf-2,Cf2,F2,FII,PT,RPRGL2,THPH1 |
Uniprot Accession | P00734,P18292,P00735 |
Uniprot Entry Name | THRB_HUMAN,THRB_RAT,THRB_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Type 2 diabetes mellitus with diabetic nephropathy, Thrombophlebitis |
Gene Ensembl | ENSG00000180210 |
Target Classification | N/A |
The target: F2, gene name: F2, also named as PT, RPRGL2, THPH1. This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.