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Anti-LIPP/ PNLIP/ PLD functional antibody
Anti-LIPP/ PNLIP/ PLD functional antibody for cell culture, ELISA & in-vivo assay
Go to PNLIP/PNLIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94309-Ab-1/ GM-Tg-hg-T94309-Ab-2 | Anti-Human PNLIP monoclonal antibody | Human |
| GM-Tg-rg-T94309-Ab-1/ GM-Tg-rg-T94309-Ab-2 | Anti-Rat PNLIP monoclonal antibody | Rat |
| GM-Tg-mg-T94309-Ab-1/ GM-Tg-mg-T94309-Ab-2 | Anti-Mouse PNLIP monoclonal antibody | Mouse |
| GM-Tg-cynog-T94309-Ab-1/ GM-Tg-cynog-T94309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PNLIP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94309-Ab-1/ GM-Tg-felg-T94309-Ab-2 | Anti-Feline PNLIP monoclonal antibody | Feline |
| GM-Tg-cang-T94309-Ab-1/ GM-Tg-cang-T94309-Ab-2 | Anti-Canine PNLIP monoclonal antibody | Canine |
| GM-Tg-bovg-T94309-Ab-1/ GM-Tg-bovg-T94309-Ab-2 | Anti-Bovine PNLIP monoclonal antibody | Bovine |
| GM-Tg-equg-T94309-Ab-1/ GM-Tg-equg-T94309-Ab-2 | Anti-Equine PNLIP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94309-Ab-1/ GM-Tg-hg-T94309-Ab-2; GM-Tg-rg-T94309-Ab-1/ GM-Tg-rg-T94309-Ab-2; GM-Tg-mg-T94309-Ab-1/ GM-Tg-mg-T94309-Ab-2; GM-Tg-cynog-T94309-Ab-1/ GM-Tg-cynog-T94309-Ab-2; GM-Tg-felg-T94309-Ab-1/ GM-Tg-felg-T94309-Ab-2; GM-Tg-cang-T94309-Ab-1/ GM-Tg-cang-T94309-Ab-2; GM-Tg-bovg-T94309-Ab-1/ GM-Tg-bovg-T94309-Ab-2; GM-Tg-equg-T94309-Ab-1/ GM-Tg-equg-T94309-Ab-2 |
| Products Name | Anti-PNLIP monoclonal antibody |
| Format | mab |
| Target Name | PNLIP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PNLIP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T94309-Ag-1 | Recombinant multi-species LIPP/ PNLIP/ PLD protein |
| ORF Viral Vector | vGMLP002927 | human PNLIP Lentivirus particle |
| ORF Viral Vector | pGMLP002927 | human PNLIP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001624 | mouse Pnlip Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001624 | mouse Pnlip Lentivirus particle |
Target information
| Target ID | GM-T94309 |
| Target Name | PNLIP |
| Gene ID | 5406,69060,25702,706689,477830,101083211,100034202 |
| Gene Symbol and Synonyms | 1810007A24Rik,LIPASE,PANLI,PL,PNLIP,PNLIPD,PTL |
| Uniprot Accession | P16233,P27657,P29183 |
| Uniprot Entry Name | LIPP_HUMAN,LIPP_RAT,LIPP_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000175535 |
| Target Classification | N/A |
The target: PNLIP, gene name: PNLIP, also named as PLD, PTL, PNLIP. This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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