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Anti-LDLR/ LDL-R/ FH monoclonal antibody
Anti-LDLR/ LDL-R/ FH antibody for FACS & in-vivo assay
Go to LDL-R/LDLR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
SDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94692-Ab-1/ GM-Tg-hg-T94692-Ab-2 | Anti-Human LDL-R/LDLR monoclonal antibody | Human |
| GM-Tg-rg-T94692-Ab-1/ GM-Tg-rg-T94692-Ab-2 | Anti-Rat LDL-R/LDLR monoclonal antibody | Rat |
| GM-Tg-mg-T94692-Ab-1/ GM-Tg-mg-T94692-Ab-2 | Anti-Mouse LDL-R/LDLR monoclonal antibody | Mouse |
| GM-Tg-cynog-T94692-Ab-1/ GM-Tg-cynog-T94692-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LDL-R/LDLR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94692-Ab-1/ GM-Tg-felg-T94692-Ab-2 | Anti-Feline LDL-R/LDLR monoclonal antibody | Feline |
| GM-Tg-cang-T94692-Ab-1/ GM-Tg-cang-T94692-Ab-2 | Anti-Canine LDL-R/LDLR monoclonal antibody | Canine |
| GM-Tg-bovg-T94692-Ab-1/ GM-Tg-bovg-T94692-Ab-2 | Anti-Bovine LDL-R/LDLR monoclonal antibody | Bovine |
| GM-Tg-equg-T94692-Ab-1/ GM-Tg-equg-T94692-Ab-2 | Anti-Equine LDL-R/LDLR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94692-Ab-1/ GM-Tg-hg-T94692-Ab-2; GM-Tg-rg-T94692-Ab-1/ GM-Tg-rg-T94692-Ab-2; GM-Tg-mg-T94692-Ab-1/ GM-Tg-mg-T94692-Ab-2; GM-Tg-cynog-T94692-Ab-1/ GM-Tg-cynog-T94692-Ab-2; GM-Tg-felg-T94692-Ab-1/ GM-Tg-felg-T94692-Ab-2; GM-Tg-cang-T94692-Ab-1/ GM-Tg-cang-T94692-Ab-2; GM-Tg-bovg-T94692-Ab-1/ GM-Tg-bovg-T94692-Ab-2; GM-Tg-equg-T94692-Ab-1/ GM-Tg-equg-T94692-Ab-2 |
| Products Name | Anti-LDL-R/LDLR monoclonal antibody |
| Format | mab |
| Target Name | LDL-R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LDL-R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T94692-Ag-1 | Multi-species LDLR/ LDL-R/ FH VLP (virus-like particle) |
| ORF Viral Vector | vGMLP005154 | human LDLR Lentivirus particle |
| ORF Viral Vector | pGMLP005154 | human LDLR Lentivirus plasmid |
Target information
| Target ID | GM-T94692 |
| Target Name | LDL-R |
| Gene ID | 3949,16835,300438,574283,100683160,101080362,281276,100057389 |
| Gene Symbol and Synonyms | FH,FHC,FHCL1,Hlb301,LDLCQ2,LDLR,LDLRA |
| Uniprot Accession | P01130,P35952,P01131 |
| Uniprot Entry Name | LDLR_HUMAN,LDLR_RAT,LDLR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000130164 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LDL-R, gene name: LDLR, also named as FH, FHC, LDLCQ2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s TaurusTM and LIBRATM platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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