Anti-BGLR/ GUSB/ BG functional antibody
Anti-BGLR/ GUSB/ BG functional antibody for cell culture, ELISA & in-vivo assay
Go to GUSB/GUSB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T96413-Ab-1/ GM-Tg-hg-T96413-Ab-2 | Anti-Human GUSB monoclonal antibody | Human |
GM-Tg-rg-T96413-Ab-1/ GM-Tg-rg-T96413-Ab-2 | Anti-Rat GUSB monoclonal antibody | Rat |
GM-Tg-mg-T96413-Ab-1/ GM-Tg-mg-T96413-Ab-2 | Anti-Mouse GUSB monoclonal antibody | Mouse |
GM-Tg-cynog-T96413-Ab-1/ GM-Tg-cynog-T96413-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GUSB monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T96413-Ab-1/ GM-Tg-felg-T96413-Ab-2 | Anti-Feline GUSB monoclonal antibody | Feline |
GM-Tg-cang-T96413-Ab-1/ GM-Tg-cang-T96413-Ab-2 | Anti-Canine GUSB monoclonal antibody | Canine |
GM-Tg-bovg-T96413-Ab-1/ GM-Tg-bovg-T96413-Ab-2 | Anti-Bovine GUSB monoclonal antibody | Bovine |
GM-Tg-equg-T96413-Ab-1/ GM-Tg-equg-T96413-Ab-2 | Anti-Equine GUSB monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T96413-Ab-1/ GM-Tg-hg-T96413-Ab-2; GM-Tg-rg-T96413-Ab-1/ GM-Tg-rg-T96413-Ab-2; GM-Tg-mg-T96413-Ab-1/ GM-Tg-mg-T96413-Ab-2; GM-Tg-cynog-T96413-Ab-1/ GM-Tg-cynog-T96413-Ab-2; GM-Tg-felg-T96413-Ab-1/ GM-Tg-felg-T96413-Ab-2; GM-Tg-cang-T96413-Ab-1/ GM-Tg-cang-T96413-Ab-2; GM-Tg-bovg-T96413-Ab-1/ GM-Tg-bovg-T96413-Ab-2; GM-Tg-equg-T96413-Ab-1/ GM-Tg-equg-T96413-Ab-2 |
Products Name | Anti-GUSB monoclonal antibody |
Format | mab |
Target Name | GUSB |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-GUSB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T96413-Ag-1 | Recombinant multi-species BGLR/ GUSB/ BG protein |
ORF Viral Vector | pGMLP002111 | human GUSB Lentivirus plasmid |
ORF Viral Vector | vGMLP002111 | human GUSB Lentivirus particle |
ORF Viral Vector | pGMLPm004958 | mouse Gusb Lentivirus plasmid |
ORF Viral Vector | vGMLPm004958 | mouse Gusb Lentivirus particle |
Target information
Target ID | GM-T96413 |
Target Name | GUSB |
Gene ID | 2990,110006,24434,403831,493879,515687,100037416 |
Gene Symbol and Synonyms | Ac2-223,asd,BG,g,Gur,Gus,Gus-r,Gus-s,Gus-t,Gus-u,GUSB,Gut,MPS7 |
Uniprot Accession | P08236,P06760,O18835,O97524 |
Uniprot Entry Name | BGLR_HUMAN,BGLR_RAT,BGLR_FELCA,BGLR_CANLF |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000169919 |
Target Classification | Tumor-associated antigen (TAA) |
The target: GUSB, gene name: GUSB, also named as BG, MPS7. This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.