Anti-MELK/ HPK38 monoclonal antibody

Anti-MELK/ HPK38 antibody for FACS & in-vivo assay

Target products collectionGo to MELK/MELK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T96892-Ab-1/ GM-Tg-hg-T96892-Ab-2Anti-Human MELK monoclonal antibodyHuman
GM-Tg-rg-T96892-Ab-1/ GM-Tg-rg-T96892-Ab-2Anti-Rat MELK monoclonal antibodyRat
GM-Tg-mg-T96892-Ab-1/ GM-Tg-mg-T96892-Ab-2Anti-Mouse MELK monoclonal antibodyMouse
GM-Tg-cynog-T96892-Ab-1/ GM-Tg-cynog-T96892-Ab-2Anti-Cynomolgus/ Rhesus macaque MELK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T96892-Ab-1/ GM-Tg-felg-T96892-Ab-2Anti-Feline MELK monoclonal antibodyFeline
GM-Tg-cang-T96892-Ab-1/ GM-Tg-cang-T96892-Ab-2Anti-Canine MELK monoclonal antibodyCanine
GM-Tg-bovg-T96892-Ab-1/ GM-Tg-bovg-T96892-Ab-2Anti-Bovine MELK monoclonal antibodyBovine
GM-Tg-equg-T96892-Ab-1/ GM-Tg-equg-T96892-Ab-2Anti-Equine MELK monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T96892-Ab-1/ GM-Tg-hg-T96892-Ab-2; GM-Tg-rg-T96892-Ab-1/ GM-Tg-rg-T96892-Ab-2;
GM-Tg-mg-T96892-Ab-1/ GM-Tg-mg-T96892-Ab-2; GM-Tg-cynog-T96892-Ab-1/ GM-Tg-cynog-T96892-Ab-2;
GM-Tg-felg-T96892-Ab-1/ GM-Tg-felg-T96892-Ab-2; GM-Tg-cang-T96892-Ab-1/ GM-Tg-cang-T96892-Ab-2;
GM-Tg-bovg-T96892-Ab-1/ GM-Tg-bovg-T96892-Ab-2; GM-Tg-equg-T96892-Ab-1/ GM-Tg-equg-T96892-Ab-2
Products NameAnti-MELK monoclonal antibody
Formatmab
Target NameMELK
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MELK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MELK/ HPK38 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T96892
    Target NameMELK
    Gene ID9833,17279,362510,716875,481608,101099597,520088,100055291
    Gene Symbol and SynonymsHPK38,MELK,mKIAA0175,MPK38
    Uniprot AccessionQ14680
    Uniprot Entry NameMELK_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000165304
    Target ClassificationKinase

    The target: MELK, gene name: MELK, also named as HPK38. Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.