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Anti-MTR1A/ MTNR1A/ MEL-1A-R monoclonal antibody
Anti-MTR1A/ MTNR1A/ MEL-1A-R antibody for FACS & in-vivo assay
Go to MTNR1A/MTNR1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T97613-Ab-1/ GM-Tg-hg-T97613-Ab-2 | Anti-Human MTNR1A monoclonal antibody | Human |
| GM-Tg-rg-T97613-Ab-1/ GM-Tg-rg-T97613-Ab-2 | Anti-Rat MTNR1A monoclonal antibody | Rat |
| GM-Tg-mg-T97613-Ab-1/ GM-Tg-mg-T97613-Ab-2 | Anti-Mouse MTNR1A monoclonal antibody | Mouse |
| GM-Tg-cynog-T97613-Ab-1/ GM-Tg-cynog-T97613-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MTNR1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T97613-Ab-1/ GM-Tg-felg-T97613-Ab-2 | Anti-Feline MTNR1A monoclonal antibody | Feline |
| GM-Tg-cang-T97613-Ab-1/ GM-Tg-cang-T97613-Ab-2 | Anti-Canine MTNR1A monoclonal antibody | Canine |
| GM-Tg-bovg-T97613-Ab-1/ GM-Tg-bovg-T97613-Ab-2 | Anti-Bovine MTNR1A monoclonal antibody | Bovine |
| GM-Tg-equg-T97613-Ab-1/ GM-Tg-equg-T97613-Ab-2 | Anti-Equine MTNR1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T97613-Ab-1/ GM-Tg-hg-T97613-Ab-2; GM-Tg-rg-T97613-Ab-1/ GM-Tg-rg-T97613-Ab-2; GM-Tg-mg-T97613-Ab-1/ GM-Tg-mg-T97613-Ab-2; GM-Tg-cynog-T97613-Ab-1/ GM-Tg-cynog-T97613-Ab-2; GM-Tg-felg-T97613-Ab-1/ GM-Tg-felg-T97613-Ab-2; GM-Tg-cang-T97613-Ab-1/ GM-Tg-cang-T97613-Ab-2; GM-Tg-bovg-T97613-Ab-1/ GM-Tg-bovg-T97613-Ab-2; GM-Tg-equg-T97613-Ab-1/ GM-Tg-equg-T97613-Ab-2 |
| Products Name | Anti-MTNR1A monoclonal antibody |
| Format | mab |
| Target Name | MTNR1A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MTNR1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MTR1A/ MTNR1A/ MEL-1A-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003856 | human MTNR1A Lentivirus particle |
| ORF Viral Vector | pGMLP003856 | human MTNR1A Lentivirus plasmid |
Target information
| Target ID | GM-T97613 |
| Target Name | MTNR1A |
| Gene ID | 4543,17773,114211,702686,482904,101098297,539948,100056423 |
| Gene Symbol and Synonyms | MEL-1A-R,MelR,MR,MT1,MTNR1A |
| Uniprot Accession | P48039,P49218,O02769 |
| Uniprot Entry Name | MTR1A_HUMAN,MTR1A_RAT,MTR1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000168412 |
| Target Classification | GPCR |
The target: MTNR1A, gene name: MTNR1A, also named as MEL-1A-R, MT1. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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