Anti-PTHY/ PTH/ PTH1 functional antibody

Anti-PTHY/ PTH/ PTH1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PTH/PTH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T98708-Ab-1/ GM-Tg-hg-T98708-Ab-2Anti-Human PTH monoclonal antibodyHuman
GM-Tg-rg-T98708-Ab-1/ GM-Tg-rg-T98708-Ab-2Anti-Rat PTH monoclonal antibodyRat
GM-Tg-mg-T98708-Ab-1/ GM-Tg-mg-T98708-Ab-2Anti-Mouse PTH monoclonal antibodyMouse
GM-Tg-cynog-T98708-Ab-1/ GM-Tg-cynog-T98708-Ab-2Anti-Cynomolgus/ Rhesus macaque PTH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T98708-Ab-1/ GM-Tg-felg-T98708-Ab-2Anti-Feline PTH monoclonal antibodyFeline
GM-Tg-cang-T98708-Ab-1/ GM-Tg-cang-T98708-Ab-2Anti-Canine PTH monoclonal antibodyCanine
GM-Tg-bovg-T98708-Ab-1/ GM-Tg-bovg-T98708-Ab-2Anti-Bovine PTH monoclonal antibodyBovine
GM-Tg-equg-T98708-Ab-1/ GM-Tg-equg-T98708-Ab-2Anti-Equine PTH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T98708-Ab-1/ GM-Tg-hg-T98708-Ab-2; GM-Tg-rg-T98708-Ab-1/ GM-Tg-rg-T98708-Ab-2;
GM-Tg-mg-T98708-Ab-1/ GM-Tg-mg-T98708-Ab-2; GM-Tg-cynog-T98708-Ab-1/ GM-Tg-cynog-T98708-Ab-2;
GM-Tg-felg-T98708-Ab-1/ GM-Tg-felg-T98708-Ab-2; GM-Tg-cang-T98708-Ab-1/ GM-Tg-cang-T98708-Ab-2;
GM-Tg-bovg-T98708-Ab-1/ GM-Tg-bovg-T98708-Ab-2; GM-Tg-equg-T98708-Ab-1/ GM-Tg-equg-T98708-Ab-2
Products NameAnti-PTH monoclonal antibody
Formatmab
Target NamePTH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T98708-Ag-1Recombinant multi-species PTHY/ PTH/ PTH1 protein
    ORF Viral VectorvGMLP001900human PTH Lentivirus particle
    ORF Viral VectorpGMLP001900human PTH Lentivirus plasmid
    ORF Viral VectorpGMAAV000076mouse Pth AAV plasmid
    ORF Viral VectorvGMAAV000076mouse Pth AAV particle


    Target information

    Target IDGM-T98708
    Target NamePTH
    Gene ID5741,19226,24694,700195,403986,493684,280903,100034104
    Gene Symbol and SynonymsFIH1,PTH,PTH-(1-84),PTH1,Pthp,Pthr1
    Uniprot AccessionP01270,P04089,P52212,Q9GL67,P01268,Q27IM2
    Uniprot Entry NamePTHY_HUMAN,PTHY_RAT,PTHY_FELCA,PTHY_CANLF,PTHY_BOVIN,PTHY_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseN/A
    Gene EnsemblENSG00000152266
    Target ClassificationN/A

    The target: PTH, gene name: PTH, also named as PTH1. This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.