Anti-PTHY/ PTH/ PTH1 functional antibody
Anti-PTHY/ PTH/ PTH1 functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T98708-Ab-1/ GM-Tg-hg-T98708-Ab-2 | Anti-Human PTH monoclonal antibody | Human |
GM-Tg-rg-T98708-Ab-1/ GM-Tg-rg-T98708-Ab-2 | Anti-Rat PTH monoclonal antibody | Rat |
GM-Tg-mg-T98708-Ab-1/ GM-Tg-mg-T98708-Ab-2 | Anti-Mouse PTH monoclonal antibody | Mouse |
GM-Tg-cynog-T98708-Ab-1/ GM-Tg-cynog-T98708-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTH monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T98708-Ab-1/ GM-Tg-felg-T98708-Ab-2 | Anti-Feline PTH monoclonal antibody | Feline |
GM-Tg-cang-T98708-Ab-1/ GM-Tg-cang-T98708-Ab-2 | Anti-Canine PTH monoclonal antibody | Canine |
GM-Tg-bovg-T98708-Ab-1/ GM-Tg-bovg-T98708-Ab-2 | Anti-Bovine PTH monoclonal antibody | Bovine |
GM-Tg-equg-T98708-Ab-1/ GM-Tg-equg-T98708-Ab-2 | Anti-Equine PTH monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T98708-Ab-1/ GM-Tg-hg-T98708-Ab-2; GM-Tg-rg-T98708-Ab-1/ GM-Tg-rg-T98708-Ab-2; GM-Tg-mg-T98708-Ab-1/ GM-Tg-mg-T98708-Ab-2; GM-Tg-cynog-T98708-Ab-1/ GM-Tg-cynog-T98708-Ab-2; GM-Tg-felg-T98708-Ab-1/ GM-Tg-felg-T98708-Ab-2; GM-Tg-cang-T98708-Ab-1/ GM-Tg-cang-T98708-Ab-2; GM-Tg-bovg-T98708-Ab-1/ GM-Tg-bovg-T98708-Ab-2; GM-Tg-equg-T98708-Ab-1/ GM-Tg-equg-T98708-Ab-2 |
Products Name | Anti-PTH monoclonal antibody |
Format | mab |
Target Name | PTH |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-PTH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T98708-Ag-1 | Recombinant multi-species PTHY/ PTH/ PTH1 protein |
ORF Viral Vector | vGMLP001900 | human PTH Lentivirus particle |
ORF Viral Vector | pGMLP001900 | human PTH Lentivirus plasmid |
ORF Viral Vector | pGMAAV000076 | mouse Pth AAV plasmid |
ORF Viral Vector | vGMAAV000076 | mouse Pth AAV particle |
Target information
Target ID | GM-T98708 |
Target Name | PTH |
Gene ID | 5741,19226,24694,700195,403986,493684,280903,100034104 |
Gene Symbol and Synonyms | FIH1,PTH,PTH-(1-84),PTH1,Pthp,Pthr1 |
Uniprot Accession | P01270,P04089,P52212,Q9GL67,P01268,Q27IM2 |
Uniprot Entry Name | PTHY_HUMAN,PTHY_RAT,PTHY_FELCA,PTHY_CANLF,PTHY_BOVIN,PTHY_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target, Diagnostics Biomarker |
Disease | N/A |
Gene Ensembl | ENSG00000152266 |
Target Classification | N/A |
The target: PTH, gene name: PTH, also named as PTH1. This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.