Bovine Aβ42 antibody and antigen (recombinant protein)

Diagnostic anti-Bovine Aβ42 antibodies pairs and antigen for animal health (animal Bovines/Cattle Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-BOV-AB42-Ag01Bovine Aβ42$3090.00
GMP-BOV-AB42-Ab01Anti-Bovine Aβ42 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-AB42-Ab02Anti-Bovine Aβ42 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-AB42-Ab03Anti-Bovine Aβ42 human monoclonal antibody (mAb)$3090.00
GMP-BOV-AB42-Ab04Anti-Bovine Aβ42 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-BOV-AB42-Ag01
Product NameBovine Aβ42
Target/BiomarkerBovine Aβ42
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Bovine Aβ42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ42 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsBovine Aβ42
Product descriptionRecombinant Bovine Aβ42 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-AB42-Ab01,GMP-BOV-AB42-Ab02
Target/BiomarkerBovine Aβ42
Product NameAnti-Bovine Aβ42 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Bovine Aβ42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Aβ42 antibodies in Bovine Aβ42 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine Aβ42 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Aβ42 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-AB42-Ab03,GMP-BOV-AB42-Ab04
Target/BiomarkerBovine Aβ42
Product NameAnti-Bovine Aβ42 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Bovine Aβ42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Aβ42 antibodies in Bovine Aβ42 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine Aβ42 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Bovine Amyloid-beta 42 (Aβ42) is a remarkable molecule in bovine neuropathology, occupying a central role in our understanding of neurodegenerative conditions afflicting cattle. Comprising 42 amino acids, Aβ42 is a fragment of the amyloid precursor protein (APP) and serves as a critical component in the formation of amyloid plaques within the bovine brain. These plaques, primarily composed of Aβ42, are emblematic pathological features associated with cognitive dysfunction in cattle, most notably in cases of bovine spongiform encephalopathy (BSE), colloquially referred to as "mad cow disease."

    The generation of Aβ42 occurs through the proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In cattle afflicted by BSE, an aberration in Aβ42 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neural function, contributing significantly to cognitive deficits, neural degeneration, and the clinical manifestations observed in affected cattle.

    The implications of Aβ42 aggregation extend further, encompassing a cascade of pathological events. These include neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively exacerbate the neurodegenerative processes occurring in cattle suffering from BSE.



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    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.