Bovine Haptoglobin antibody and antigen (recombinant protein)

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Diagnostic anti-Bovine Haptoglobin antibodies pairs and antigen for animal health (animal Bovines/Cattle milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-Haptoglobin-Ag01	Bovine Haptoglobin	$3090.00
GMP-BOV-Haptoglobin-Ab01	Anti-Bovine Haptoglobin mouse monoclonal antibody (mAb)	$3090.00
GMP-BOV-Haptoglobin-Ab02	Anti-Bovine Haptoglobin mouse monoclonal antibody (mAb)	$3090.00
GMP-BOV-Haptoglobin-Ab03	Anti-Bovine Haptoglobin human monoclonal antibody (mAb)	$3090.00
GMP-BOV-Haptoglobin-Ab04	Anti-Bovine Haptoglobin human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-BOV-Haptoglobin-Ag01
Product Name	Bovine Haptoglobin
Target/Biomarker	Bovine Haptoglobin
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Haptoglobin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Bovine Haptoglobin level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	His
Reconized/Reactive Specics	Bovine Haptoglobin
Product description	Recombinant Bovine Haptoglobin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-BOV-Haptoglobin-Ab01,GMP-BOV-Haptoglobin-Ab02
Target/Biomarker	Bovine Haptoglobin
Product Name	Anti-Bovine Haptoglobin mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Haptoglobin antibodies in Bovine Haptoglobin level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Product description	Anti-Bovine Haptoglobin mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Haptoglobin antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-BOV-Haptoglobin-Ab03,GMP-BOV-Haptoglobin-Ab04
Target/Biomarker	Bovine Haptoglobin
Product Name	Anti-Bovine Haptoglobin human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Bovine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Haptoglobin antibodies in Bovine Haptoglobin level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Product description	Anti-Bovine Haptoglobin mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker Information

The measurement of Bovine Haptoglobin levels transcends the realm of routine diagnostics; it is a gateway to comprehensive bovine healthcare, offering profound insights into the immune response, disease diagnosis, and research pursuits, ultimately enhancing the well-being of cattle and advancing veterinary science.

At the forefront of its significance is Haptoglobin's role as a sensitive and specific biomarker of inflammation and infection in cattle. Elevated Haptoglobin levels are indicative of an ongoing inflammatory response within the bovine body. The magnitude of this elevation can offer critical information about the nature and severity of the underlying condition. Veterinarians rely on Haptoglobin measurements to diagnose and monitor various diseases and infections in cattle, ranging from respiratory infections to mastitis.

Furthermore, Haptoglobin measurements are invaluable for the timely initiation of therapeutic interventions. Inflammatory conditions and infections in cattle can escalate rapidly, leading to serious health consequences if left unchecked. Haptoglobin levels serve as an early warning system, allowing veterinarians to promptly identify health issues and implement appropriate treatment strategies. This proactive approach minimizes suffering, prevents disease progression, and optimizes the chances of a successful recovery.

In addition to its diagnostic utility, Haptoglobin measurements hold a pivotal place in bovine research endeavors. Scientists leverage these measurements to gain insights into the bovine immune response and its dynamics. By monitoring Haptoglobin levels in experimental studies, researchers can investigate how cattle react to various challenges, including infections, dietary alterations, and stressors. This information deepens our understanding of bovine immunology, paving the way for the development of novel therapies and preventive strategies.

Moreover, Haptoglobin measurements have implications in the context of herd health management. Farmers and ranchers can employ these measurements to assess the overall health status of their cattle populations. Monitoring Haptoglobin levels can reveal hidden health issues, even in apparently healthy animals, allowing for targeted interventions to maintain herd well-being and productivity.

Additionally, Haptoglobin measurements offer insights into the response of cattle to stressors, including transportation and environmental changes. Elevated Haptoglobin levels in such situations can serve as an indicator of stress-related immune responses, prompting farmers and veterinarians to implement stress-reduction strategies.

In summation, the measurement of Bovine Haptoglobin levels is a multifaceted endeavor that bridges the realms of clinical diagnostics, research, and herd management. Its clinical utility encompasses the diagnosis and monitoring of diseases and infections, with a focus on timely interventions and improved cattle health. Simultaneously, it fuels the engine of scientific exploration, advancing our understanding of bovine immunology, and offering opportunities to enhance cattle well-being and agricultural sustainability. Haptoglobin emerges as a sentinel of bovine health, guiding the path towards optimal herd management and scientific discovery., Bovine Haptoglobin, an indispensable component of the bovine immune system, stands as a sentinel of inflammation and infection within the cattle body. Structurally, it is a glycoprotein synthesized primarily in the hepatocytes of the liver, spurred into production by the clarion call of pro-inflammatory cytokines, particularly interleukin-6 (IL-6).

The central function of Bovine Haptoglobin revolves around its remarkable ability to bind free hemoglobin molecules. When red blood cells succumb to damage or lysis, hemoglobin is released into the bloodstream, where it could potentially wreak havoc. Free hemoglobin, in its unbridled state, can induce oxidative damage and may precipitate kidney filtration, leading to renal damage. Haptoglobin, ever vigilant, steps in to avert this crisis. It swiftly forms stable complexes with free hemoglobin, rendering it inert and facilitating its clearance by the reticuloendothelial system.

The significance of this hemoglobin-binding function cannot be overstated. By sequestering free hemoglobin, Haptoglobin serves as a guardian against the adverse consequences of hemolysis, preserving the integrity of the bovine circulatory system and minimizing the risk of oxidative damage.

Beyond its hemoglobin-binding role, Haptoglobin exhibits intriguing immunomodulatory properties. It possesses the capability to interact with immune cells, contributing to the modulation of the inflammatory response. In this capacity, Haptoglobin assumes the role of an immunological maestro, orchestrating the actions of immune cells to address specific threats. This immunomodulation may involve the regulation of cytokine production, influencing the recruitment of immune cells to the site of infection, or modulating the phagocytic activity of macrophages.

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