Bovine cIV antibody and antigen (recombinant protein)

Diagnostic anti-Bovine cIV antibodies pairs and antigen for animal health (animal Bovines/Cattle Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury.) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-cIV-Ag01	Bovine cIV	$3090.00
GMP-BOV-cIV-Ab01	Anti-Bovine cIV mouse monoclonal antibody (mAb)	$3090.00
GMP-BOV-cIV-Ab02	Anti-Bovine cIV mouse monoclonal antibody (mAb)	$3090.00
GMP-BOV-cIV-Ab03	Anti-Bovine cIV human monoclonal antibody (mAb)	$3090.00
GMP-BOV-cIV-Ab04	Anti-Bovine cIV human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-BOV-cIV-Ag01
Product Name	Bovine cIV
Target/Biomarker	Bovine cIV
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine cIV antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cIV level test of animal Bovines/Cattle with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Tag	His
Reconized/Reactive Specics	Bovine cIV
Product description	Recombinant Bovine cIV protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-BOV-cIV-Ab01,GMP-BOV-cIV-Ab02
Target/Biomarker	Bovine cIV
Product Name	Anti-Bovine cIV mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine cIV antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine cIV antibodies in Bovine cIV level test of animal Bovines/Cattle with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Product description	Anti-Bovine cIV mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine cIV antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-BOV-cIV-Ab03,GMP-BOV-cIV-Ab04
Target/Biomarker	Bovine cIV
Product Name	Anti-Bovine cIV human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Bovine cIV antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine cIV antibodies in Bovine cIV level test of animal Bovines/Cattle with Goodpasture syndrome, Alport syndrome, glomerular basement membrane, Liver fibrosis and cirrhosis, alcoholic liver disease, hepatitis C and fall following successful therapy. autosomal dominant hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. porencephaly, schizencephaly, congenital cataract, coronary artery disease, diabetic nephropathy and renal injury..
Product description	Anti-Bovine cIV mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker Information

Bovine Cardiac Troponin I (cTnI) is a remarkable biomarker that takes center stage in the intricate choreography of bovine cardiac muscle contraction. As a species-specific protein found exclusively within the cardiac muscle of cattle, cTnI assumes a pivotal role in ensuring the rhythmic and effective pumping of blood through the bovine circulatory system.

Structurally, cTnI forms part of the troponin complex, a trio of proteins that governs the contractile activity of muscle fibers. This complex includes cTnI (inhibitory subunit), cTnT (tropomyosin-binding subunit), and cTnC (calcium-binding subunit). Among these, cTnI is the conductor of the orchestra, orchestrating the symphony of cardiac muscle contraction.

The core function of cTnI lies in its ability to regulate the interaction between actin and myosin—the two major proteins involved in muscle contraction. In the absence of calcium ions (Ca2+), cTnI binds to actin, effectively preventing the interaction between actin and myosin. This inhibition ensures that the heart remains relaxed and at rest when not pumping blood.

However, when the heart receives the signal to contract, typically in response to an electrical impulse, calcium ions (Ca2+) flood into the cardiac muscle cell. This influx of Ca2+ induces a conformational change in cTnI, releasing its grip on actin. With this inhibitory hold released, actin and myosin can now interact, initiating the process of muscle contraction. This synchronized and highly regulated dance of proteins is what enables the bovine heart to contract efficiently, pumping blood to nourish vital organs and tissues.

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