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Canine Aβ40 antibody and antigen (recombinant protein)
Diagnostic anti-Canine Aβ40 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
| Catalog No. | Description | US $ Price (per mg) |
|---|---|---|
| GMP-CAN-AB40-Ag01 | Canine Aβ40 | $3090.00 |
| GMP-CAN-AB40-Ab01 | Anti-Canine Aβ40 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-AB40-Ab02 | Anti-Canine Aβ40 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-AB40-Ab03 | Anti-Canine Aβ40 human monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-AB40-Ab04 | Anti-Canine Aβ40 human monoclonal antibody (mAb) | $3090.00 |
Size： 1mg | 10mg | 100mg
Product Description
| Cat No. | GMP-CAN-AB40-Ag01 |
| Product Name | Canine Aβ40 |
| Target/Biomarker | Canine Aβ40 |
| Expression platform | E.coli |
| Isotypes | Recombinant Antigen |
| Bioactivity validation | Anti-Canine Aβ40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ40 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Tag | His | Reconized/Reactive Specics | Canine Aβ40 |
| Product description | Recombinant Canine Aβ40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-CAN-AB40-Ab01,GMP-CAN-AB40-Ab02 |
| Target/Biomarker | Canine Aβ40 |
| Product Name | Anti-Canine Aβ40 mouse monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Mouse IgG |
| Bioactivity validation | Recombinant Canine Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Aβ40 antibodies in Canine Aβ40 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Product description | Anti-Canine Aβ40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Aβ40 antibodies. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-CAN-AB40-Ab03,GMP-CAN-AB40-Ab04 |
| Target/Biomarker | Canine Aβ40 |
| Product Name | Anti-Canine Aβ40 human monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Human lgG1 |
| Bioactivity validation | Recombinant Canine Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Aβ40 antibodies in Canine Aβ40 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Product description | Anti-Canine Aβ40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Target/Biomarker Information
Canine Amyloid-beta 40 (Aβ40) stands as a pivotal molecule in canine neuroscience, assuming a central role in our understanding of neurodegenerative conditions affecting our beloved canine companions. Comprising 40 amino acids, Aβ40 is a fragment of the amyloid precursor protein (APP) and represents a critical component in the formation of amyloid plaques within the canine brain. These plaques, predominantly composed of Aβ40, are emblematic of cognitive decline in dogs, most notably in cases of canine cognitive dysfunction syndrome (CCDS).
The genesis of Aβ40 involves proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In dogs afflicted by CCDS, an imbalance in Aβ40 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neural function, contributing substantially to the cognitive deficits and memory impairments observed in affected dogs.
The implications of Aβ40 aggregation transcend cognitive deficits. Aβ40 aggregates can trigger neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively contribute to the progressive neurological decline seen in dogs suffering from CCDS.
About GDU
GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.
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