Canine ApoA antibody and antigen (recombinant protein)

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Diagnostic anti-Canine ApoA antibodies pairs and antigen for animal health (animal Dog/Canine Cardiovascular Disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

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Target/Biomarker Information

 Canine ApoA, or Canine Apolipoprotein A, represents a sophisticated facet of the canine physiological landscape. Within the intricate tapestry of a dog's biochemistry, this protein takes on a pivotal role, influencing lipid metabolism and cardiovascular health in profound ways.

At its core, Canine ApoA is a member of the apolipoprotein family, a group of proteins recognized for their capacity to modulate lipid transport through the circulatory system. Apolipoproteins are like molecular shepherds, guiding lipids (fats) throughout the bloodstream, ensuring they reach their intended destinations for various physiological processes.

Canine ApoA, in particular, is primarily synthesized within the liver, where it undergoes an intricate series of modifications before being released into the bloodstream. This protein plays a critical role in the formation and maintenance of high-density lipoproteins (HDL), colloquially known as "good cholesterol." HDL particles, adorned with Canine ApoA, serve as the body's lipid transport vehicles, undertaking a mission vital to a dog's well-being: the management of cholesterol and other lipids.

In its role as an HDL constituent, Canine ApoA acts as both a structural framework and a functional facilitator. Structurally, it provides stability to HDL particles, allowing them to effectively encapsulate and transport lipids through the bloodstream. Functionally, Canine ApoA participates in the process of reverse cholesterol transport (RCT), an elaborate mechanism that safeguards lipid homeostasis.

Reverse cholesterol transport is a remarkable biological circuit that ensures the removal of excess cholesterol from peripheral tissues, including arterial walls, and its return to the liver for reprocessing and eventual excretion. This process is of paramount importance because it counteracts the buildup of cholesterol in blood vessels, reducing the risk of atherosclerosis, a condition characterized by the narrowing and hardening of arteries.

The significance of Canine ApoA extends beyond its structural and functional roles. It holds a mirror to a dog's cardiovascular health, making it a target of intensive scientific study and clinical attention. Elevated levels of Canine ApoA have been correlated with a reduced risk of heart disease in dogs, indicating that this protein may serve as a biomarker for cardiac health.

Additionally, Canine ApoA is entwined with the broader landscape of lipid metabolism. Disorders in lipid metabolism can manifest as hyperlipidemia, a condition marked by abnormally high levels of lipids in the bloodstream. Monitoring Canine ApoA levels can aid veterinarians in diagnosing such conditions and crafting tailored treatment plans.

Furthermore, certain dog breeds are genetically predisposed to cardiovascular issues, and Canine ApoA measurements can provide valuable insights into their susceptibility to heart problems. Regular monitoring allows for early intervention and the implementation of preventive measures, which are especially important in breed-specific healthcare.

In conclusion, Canine ApoA, as a multifaceted player in lipid metabolism and cardiovascular health, warrants thorough scientific exploration and clinical consideration. Its role in HDL and reverse cholesterol transport showcases its importance in maintaining lipid homeostasis and reducing the risk of cardiovascular diseases in dogs. The measurement of Canine ApoA levels not only serves as a biomarker for heart health but also empowers veterinarians and pet owners to make informed decisions about a dog's well-being.

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