Canine IgG antibody and antigen (recombinant protein)

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Diagnostic anti-Canine IgG antibodies pairs and antigen for animal health (animal Dog/Canine) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-IgG-Ag01	Canine IgG	$3090.00
GMP-CAN-IgG-Ab01	Anti-Canine IgG mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-IgG-Ab02	Anti-Canine IgG mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-IgG-Ab03	Anti-Canine IgG human monoclonal antibody (mAb)	$3090.00
GMP-CAN-IgG-Ab04	Anti-Canine IgG human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-CAN-IgG-Ag01
Product Name	Canine IgG
Target/Biomarker	Canine IgG
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine IgG antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine IgG level test of animal Dog/Canine.
Tag	His
Reconized/Reactive Specics	Canine IgG
Product description	Recombinant Canine IgG protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-IgG-Ab01,GMP-CAN-IgG-Ab02
Target/Biomarker	Canine IgG
Product Name	Anti-Canine IgG mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine IgG antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies in Canine IgG level test of animal Dog/Canine.
Product description	Anti-Canine IgG mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-IgG-Ab03,GMP-CAN-IgG-Ab04
Target/Biomarker	Canine IgG
Product Name	Anti-Canine IgG human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine IgG antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine IgG antibodies in Canine IgG level test of animal Dog/Canine.
Product description	Anti-Canine IgG mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker Information

Canine Immunoglobulin G (IgG) stands as a cornerstone of the intricate canine immune system. Structurally, IgG is a glycoprotein with a Y-shaped configuration, composed of two identical heavy chains and two identical light chains, linked together by disulfide bonds. Each IgG molecule boasts remarkable specificity, with its antigen-binding regions designed to recognize and bind to a vast array of pathogens.

The production of IgG antibodies in dogs is a meticulously orchestrated process. B cells, a type of white blood cell, are activated when they encounter antigens—foreign substances or pathogens. Upon activation, B cells undergo a transformation, differentiating into plasma cells, which are specialized factories for IgG production. These plasma cells churn out copious amounts of IgG antibodies, which are then released into the bloodstream.

Canine IgG antibodies serve as vigilant sentinels, patrolling the circulatory system and tissues, ever ready to confront invading microorganisms. When they encounter an antigen they've been designed to recognize, a cascade of events is triggered. IgG binds to the antigen with high specificity, forming an antigen-antibody complex. This interaction can have several outcomes: neutralization of the pathogen, activation of other immune cells to eliminate the threat, or marking the pathogen for destruction.

One of the remarkable aspects of canine IgG is its role in providing long-lasting immunity. After an initial encounter with an antigen, memory B cells are formed. These cells "remember" the specific pathogen and can rapidly produce IgG antibodies if the same antigen enters the body again. This mechanism is the foundation of adaptive immunity and enables dogs to mount a quicker and more effective response upon reexposure to the pathogen., The measurement of Canine IgG levels transcends the realm of mere diagnostics; it is a window into the intricate workings of a dog's immune system, with profound implications for clinical practice and research endeavors.

In clinical practice, quantifying IgG levels is invaluable for assessing a dog's immune system health. A deficiency in IgG, known as hypogammaglobulinemia, can render dogs vulnerable to infections, impairing their ability to mount an effective defense against pathogens. Monitoring IgG levels is instrumental in identifying and managing immunodeficiency disorders, allowing for timely interventions to bolster the immune response.

Conversely, elevated IgG levels can signify an ongoing immune response, typically in the context of infection, inflammation, or autoimmune disorders. Measuring IgG levels provides critical diagnostic insights, guiding veterinarians in determining the underlying cause of a dog's symptoms and tailoring treatment plans accordingly.

Canine IgG measurement also assumes paramount importance in the assessment of vaccine efficacy. Vaccination is a cornerstone of preventive veterinary medicine, and IgG levels serve as a reliable indicator of a dog's immune response to vaccines. By monitoring IgG titers following vaccination, veterinarians can ensure that dogs develop sufficient protection against specific pathogens. This is especially crucial in the prevention and control of highly contagious diseases, such as canine parvovirus or distemper.

Furthermore, IgG measurement offers a nuanced perspective in the context of allergies and hypersensitivity reactions. Allergies in dogs can manifest in various ways, from skin rashes to gastrointestinal disturbances. Identifying the specific allergens triggering these responses can be challenging. However, by quantifying IgG antibodies against known allergens, veterinarians can pinpoint the culprits, facilitating targeted interventions and dietary modifications to alleviate the dog's discomfort.

Beyond the clinical realm, the measurement of Canine IgG assumes a central role in veterinary research. It provides a dynamic view of a dog's immune system status, offering insights into the response to various challenges, including infections, vaccinations, and environmental exposures. This wealth of data contributes to a deeper understanding of canine immunology, enabling researchers to explore disease mechanisms, evaluate the efficacy of novel therapies, and advance the boundaries of veterinary science.

In summation, the measurement of Canine IgG is a multifaceted tool that bridges the gap between clinical diagnostics and scientific exploration. Its clinical utility encompasses the evaluation of immune system health, disease diagnosis, vaccination monitoring, and allergy management. Simultaneously, it fuels the engine of veterinary research, propelling our understanding of canine immunology and enhancing the well-being of our beloved canine companions.

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