Canine Proinsulin antibody and antigen (recombinant protein)

Diagnostic anti-Canine Proinsulin antibodies pairs and antigen for animal health (animal Dog/Canine type 2 diabetes) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-Proinsulin-Ag01Canine Proinsulin$3090.00
GMP-CAN-Proinsulin-Ab01Anti-Canine Proinsulin mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-Proinsulin-Ab02Anti-Canine Proinsulin mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-Proinsulin-Ab03Anti-Canine Proinsulin human monoclonal antibody (mAb)$3090.00
GMP-CAN-Proinsulin-Ab04Anti-Canine Proinsulin human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-Proinsulin-Ag01
Product NameCanine Proinsulin
Target/BiomarkerCanine Proinsulin
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine Proinsulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Proinsulin level test of animal Dog/Canine with type 2 diabetes.
TagHis
Reconized/Reactive SpecicsCanine Proinsulin
Product descriptionRecombinant Canine Proinsulin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-Proinsulin-Ab01,GMP-CAN-Proinsulin-Ab02
Target/BiomarkerCanine Proinsulin
Product NameAnti-Canine Proinsulin mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Proinsulin antibodies in Canine Proinsulin level test of animal Dog/Canine with type 2 diabetes.
Product descriptionAnti-Canine Proinsulin mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Proinsulin antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-Proinsulin-Ab03,GMP-CAN-Proinsulin-Ab04
Target/BiomarkerCanine Proinsulin
Product NameAnti-Canine Proinsulin human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Proinsulin antibodies in Canine Proinsulin level test of animal Dog/Canine with type 2 diabetes.
Product descriptionAnti-Canine Proinsulin mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine Proinsulin, an 81-amino acid peptide, serves as a critical intermediate in the intricate cascade of events that culminate in the production of insulin, the hormone responsible for glucose regulation in dogs. It is synthesized and secreted by the beta cells nestled within the pancreatic islets of Langerhans, marking the initial steps in insulin biosynthesis.

    The journey of Canine Proinsulin begins with the synthesis of preproinsulin, a longer precursor molecule. Preproinsulin subsequently undergoes a remarkable transformation, folding into proinsulin, a molecule that consists of three distinct regions: the A chain, B chain, and a connecting peptide known as the C-peptide. Notably, it is this C-peptide that distinguishes proinsulin from mature insulin.

    During proinsulin processing, a series of specific enzymes operate with precision to cleave the C-peptide from proinsulin. This cleavage event marks a critical transition, as it transforms proinsulin into the active insulin molecule. The newly formed insulin is then released into circulation, where it acts as a potent regulator of glucose metabolism.

    The presence of the C-peptide within proinsulin is more than a mere structural element; it serves a physiological purpose. The C-peptide exerts beneficial effects on blood vessel health and may possess independent actions on glucose regulation. While it does not have the same glucose-lowering properties as insulin, its measurement has garnered interest in both clinical and research settings.



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