Canine relaxin antibody and antigen (recombinant protein)

Diagnostic anti-Canine relaxin antibodies pairs and antigen for animal health (animal Dog/Canine Pregnancy) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-CAN-Relaxin-Ag01 Canine relaxin $3090.00
GMP-CAN-Relaxin-Ab01 Anti-Canine relaxin mouse monoclonal antibody (mAb) $3090.00
GMP-CAN-Relaxin-Ab02 Anti-Canine relaxin mouse monoclonal antibody (mAb) $3090.00
GMP-CAN-Relaxin-Ab03 Anti-Canine relaxin human monoclonal antibody (mAb) $3090.00
GMP-CAN-Relaxin-Ab04 Anti-Canine relaxin human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-Relaxin-Ag01
Product Name Canine relaxin
Target/Biomarker Canine relaxin
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Canine relaxin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine relaxin level test of animal Dog/Canine with Pregnancy.
Tag His
Reconized/Reactive Specics Canine relaxin
Product description Recombinant Canine relaxin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-CAN-Relaxin-Ab01,GMP-CAN-Relaxin-Ab02
Target/Biomarker Canine relaxin
Product Name Anti-Canine relaxin mouse monoclonal antibody (mAb)
Expression platform Hybridoma
Isotypes Mouse IgG
Bioactivity validation Recombinant Canine relaxin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine relaxin antibodies in Canine relaxin level test of animal Dog/Canine with Pregnancy.
Product description Anti-Canine relaxin mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by hybridoma technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine relaxin antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-CAN-Relaxin-Ab03,GMP-CAN-Relaxin-Ab04
Target/Biomarker Canine relaxin
Product Name Anti-Canine relaxin human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Canine relaxin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine relaxin antibodies in Canine relaxin level test of animal Dog/Canine with Pregnancy.
Product description Anti-Canine relaxin mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Data / case study


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    Target/Biomarker Information


    Canine Relaxin (cRLX) stands as a remarkable peptide hormone in the realm of canine reproductive physiology. Synthesized primarily in the ovaries and placenta of female dogs, this hormone assumes a pivotal role in orchestrating the intricate processes that underpin pregnancy and parturition.

    Structurally, cRLX is composed of two peptide chains linked by disulfide bridges. Its production is tightly regulated and becomes particularly pronounced during pregnancy, with a significant surge in cRLX levels occurring in the second and third trimesters. This surge is not merely coincidental; it is central to ensuring a successful canine pregnancy.

    One of the hallmark functions of cRLX is its ability to induce uterine relaxation. As pregnancy progresses, the uterus must expand to accommodate the developing fetuses. The relaxation of uterine musculature, orchestrated by cRLX, is indispensable for this process. It prevents premature contractions that could jeopardize the pregnancy and ensures a safe and optimal environment for fetal growth.

    Beyond uterine relaxation, cRLX also exerts its influence on the cervix, promoting softening and dilation. These changes are vital for the passage of puppies during parturition. cRLX essentially prepares the birth canal, facilitating the smooth and efficient delivery of the offspring.

    cRLX's role extends beyond the reproductive sphere. It is involved in regulating blood vessel tone, contributing to the maternal cardiovascular adaptations necessary to support the growing fetuses. These vascular changes help ensure an adequate blood supply to both the mother and her developing litter., The measurement of cRLX in female dogs transcends the boundaries of reproductive convenience; it embodies a crucial tool with far-reaching implications for both clinical management and scientific inquiry.

    From a clinical standpoint, cRLX assays are indispensable in the diagnosis and management of various reproductive scenarios. For veterinarians and breeders, cRLX measurements offer a reliable means of confirming pregnancy and estimating its stage. The ability to predict the approximate timing of parturition is invaluable, allowing for meticulous preparation and attentive care during the critical period of whelping.

    cRLX also plays a pivotal role in assisted reproductive techniques. In cases of artificial insemination or embryo transfer, monitoring cRLX levels provides insights into the success of these interventions. A rise in cRLX concentrations post-intervention signifies a positive response, increasing the prospects of a fruitful pregnancy.

    However, the clinical significance of cRLX extends beyond reproductive optimism. It serves as a sentinel for the diagnosis of pyometra, a potentially life-threatening uterine infection that primarily afflicts intact females. Elevated cRLX levels can serve as an early indicator, prompting immediate medical intervention and potentially saving a dog's life.

    On the scientific frontier, the measurement of cRLX opens a window into the complex interplay of hormones and physiological processes governing reproduction in dogs. Researchers leverage cRLX data to unravel the intricacies of pregnancy and parturition, shedding light on the molecular mechanisms underpinning these vital events. This knowledge contributes not only to advancements in veterinary science but also to a deeper understanding of the broader field of reproductive biology.

    Moreover, the ability to monitor cRLX levels longitudinally offers a dynamic perspective on the journey of pregnancy in dogs. It provides researchers with valuable insights into the temporal changes in hormone concentrations, which can be correlated with various developmental milestones in the fetuses. Such research not only enhances our understanding of canine reproduction but also informs breeding practices and reproductive health management.

    In summation, the measurement of cRLX in female dogs embodies both clinical pragmatism and scientific curiosity. It empowers veterinarians, breeders, and researchers to navigate the intricacies of canine reproduction, ensuring the well-being of both mothers and their offspring while advancing our knowledge of this fundamental aspect of canine biology.



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