Canine S100-A8 antibody and antigen (recombinant protein)

Diagnostic anti-Canine S100-A8 antibodies pairs and antigen for animal health (animal Dog/Canine intestinal inflammation) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-S100-A8-Ag01Canine S100-A8$3090.00
GMP-CAN-S100-A8-Ab01Anti-Canine S100-A8 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-S100-A8-Ab02Anti-Canine S100-A8 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-S100-A8-Ab03Anti-Canine S100-A8 human monoclonal antibody (mAb)$3090.00
GMP-CAN-S100-A8-Ab04Anti-Canine S100-A8 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-S100-A8-Ag01
Product NameCanine S100-A8
Target/BiomarkerCanine S100-A8
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine S100-A8 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in S100-A8 level test of animal Dog/Canine with intestinal inflammation.
TagHis
Reconized/Reactive SpecicsCanine S100-A8
Product descriptionRecombinant Canine S100-A8 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-S100-A8-Ab01,GMP-CAN-S100-A8-Ab02
Target/BiomarkerCanine S100-A8
Product NameAnti-Canine S100-A8 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine S100-A8 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine S100-A8 antibodies in Canine S100-A8 level test of animal Dog/Canine with intestinal inflammation.
Product descriptionAnti-Canine S100-A8 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine S100-A8 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-S100-A8-Ab03,GMP-CAN-S100-A8-Ab04
Target/BiomarkerCanine S100-A8
Product NameAnti-Canine S100-A8 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine S100-A8 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine S100-A8 antibodies in Canine S100-A8 level test of animal Dog/Canine with intestinal inflammation.
Product descriptionAnti-Canine S100-A8 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine S100-A8, also known as Calgranulin A, stands as a linchpin in the intricate web of the canine immune system. This protein, belonging to the S100 family, is characterized by its calcium-binding properties and its profound influence on immune responses in dogs.

    Structurally, Canine S100-A8 exists as a dimeric protein, composed of two subunits, each featuring two calcium-binding EF-hand motifs. While it is primarily located within immune cells, particularly neutrophils and monocytes, it also has a presence in non-immune cells, underscoring its versatile role in modulating immune functions and inflammation.

    Upon activation of immune cells, Canine S100-A8 can be secreted into the extracellular environment, where it assumes a multifaceted role in immune regulation. It acts as a signaling molecule, communicating with other immune cells and tissues, and orchestrates an array of immune responses.

    One of its primary functions lies in regulating inflammation. Canine S100-A8 serves as a potent proinflammatory mediator, aiding in the recruitment of immune cells to sites of infection or tissue injury. It acts as a chemoattractant, guiding immune cells to the precise locations where their actions are needed. Furthermore, it plays a role in the phagocytosis of pathogens, assisting in the clearance of microbial invaders.

    Beyond its proinflammatory functions, Canine S100-A8 is also implicated in tissue repair and regeneration processes. It participates in the restoration of damaged tissues following immune responses, contributing to the resolution of inflammation and the return to normal tissue function.



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