Canine VDBP antibody and antigen (recombinant protein)

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Diagnostic anti-Canine VDBP antibodies pairs and antigen for animal health (animal Dog/Canine liver failure, type I diabetes, cystic fibrosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

Product Description

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Validation Data

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Target/Biomarker Information

Vitamin D Binding Protein (VDBP) in dogs, or canines, occupies a pivotal position in the realm of canine physiology, orchestrating the intricate ballet of vitamin D metabolism and transportation. This multifunctional protein, predominantly synthesized in the liver, plays an indispensable role in ensuring the efficient utilization of vitamin D, a vital fat-soluble nutrient for canine health.

VDBP's primary function lies in the realm of vitamin D transport. Vitamin D, whether obtained from dietary sources or synthesized in the skin through exposure to sunlight, requires a suitable carrier to navigate the aqueous environment of the bloodstream. Here, VDBP steps in as the faithful chaperone, binding to vitamin D and its metabolites, including calcidiol and calcitriol. This binding not only enhances the solubility of these compounds but also facilitates their transport to various target tissues and organs.

The importance of VDBP's transport function cannot be overstated. In the intestines, it aids in calcium absorption, a cornerstone of skeletal health in dogs. Calcium is a fundamental mineral for bone mineralization and muscle function, and its regulation is intricately tied to vitamin D. VDBP ensures that vitamin D is available in sufficient quantities to uphold calcium homeostasis, safeguarding bone integrity and overall canine well-being.

Furthermore, VDBP's reach extends beyond the realm of calcium metabolism. It plays a role in immune system modulation, influencing the immune response in dogs. By interacting with immune cells and cytokines, VDBP can potentially shape the canine immune landscape. This facet of VDBP's function opens doors to broader explorations of its impact on immune-related conditions and canine health.

The regulation of VDBP is a finely tuned process. Its synthesis is influenced by factors such as vitamin D status and hormones. When vitamin D levels are low, VDBP production increases, enhancing vitamin D transport and utilization. Conversely, when vitamin D levels are elevated, VDBP levels may decrease, preventing excessive vitamin D activity and potential toxicity.

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