Canine VDBP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-CAN-VDBP-Ag01	Recombinant Canine VDBP protein	3090
GMP-CAN-VDBP-Ab01	Anti-Canine VDBP mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-VDBP-Ab02	Anti-Canine VDBP mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-VDBP-Ab03	Anti-Canine VDBP human monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-VDBP-Ab04	Anti-Canine VDBP human monoclonal antibody (mAb)	1953	20%	1562.4

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-CAN-VDBP-Ag01
Product Name	Recombinant Canine VDBP protein
Target/Biomarker	Canine vitamin D binding protein (VDBP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine vitamin D binding protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in VDBP level test of animal Dog/Canine with liver failure, type I diabetes, cystic fibrosis.
Tag	His
Products description	Recombinant Canine VDBP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-VDBP-Ab01, GMP-CAN-VDBP-Ab02
Product Name	Anti-Canine VDBP mouse monoclonal antibody (mAb)
Target/Biomarker	Canine vitamin D binding protein (VDBP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-VDBP antibodies in VDBP level test of animal Dog/Canine with liver failure, type I diabetes, cystic fibrosis.
Tag	mFc
Products description	Anti-Canine VDBP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-VDBP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-VDBP-Ab03, GMP-CAN-VDBP-Ab04
Product Name	Anti-Canine VDBP human monoclonal antibody (mAb)
Target/Biomarker	Canine vitamin D binding protein (VDBP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Canine vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-VDBP antibodies in VDBP level test of animal Dog/Canine with liver failure, type I diabetes, cystic fibrosis.
Tag	hFc
Products description	Anti-Canine VDBP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-VDBP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Vitamin D Binding Protein (VDBP) in dogs, or canines, occupies a pivotal position in the realm of canine physiology, orchestrating the intricate ballet of vitamin D metabolism and transportation. This multifunctional protein, predominantly synthesized in the liver, plays an indispensable role in ensuring the efficient utilization of vitamin D, a vital fat-soluble nutrient for canine health. VDBP's primary function lies in the realm of vitamin D transport. Vitamin D, whether obtained from dietary sources or synthesized in the skin through exposure to sunlight, requires a suitable carrier to navigate the aqueous environment of the bloodstream. Here, VDBP steps in as the faithful chaperone, binding to vitamin D and its metabolites, including calcidiol and calcitriol. This binding not only enhances the solubility of these compounds but also facilitates their transport to various target tissues and organs. The importance of VDBP's transport function cannot be overstated. In the intestines, it aids in calcium absorption, a cornerstone of skeletal health in dogs. Calcium is a fundamental mineral for bone mineralization and muscle function, and its regulation is intricately tied to vitamin D. VDBP ensures that vitamin D is available in sufficient quantities to uphold calcium homeostasis, safeguarding bone integrity and overall canine well-being. Furthermore, VDBP's reach extends beyond the realm of calcium metabolism. It plays a role in immune system modulation, influencing the immune response in dogs. By interacting with immune cells and cytokines, VDBP can potentially shape the canine immune landscape. This facet of VDBP's function opens doors to broader explorations of its impact on immune-related conditions and canine health. The regulation of VDBP is a finely tuned process. Its synthesis is influenced by factors such as vitamin D status and hormones. When vitamin D levels are low, VDBP production increases, enhancing vitamin D transport and utilization. Conversely, when vitamin D levels are elevated, VDBP levels may decrease, preventing excessive vitamin D activity and potential toxicity.

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