Canine YKL-40 antibody and antigen (recombinant protein)

Diagnostic anti-Canine YKL-40 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-YKL-40-Ag01Canine YKL-40$3090.00
GMP-CAN-YKL-40-Ab01Anti-Canine YKL-40 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-YKL-40-Ab02Anti-Canine YKL-40 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-YKL-40-Ab03Anti-Canine YKL-40 human monoclonal antibody (mAb)$3090.00
GMP-CAN-YKL-40-Ab04Anti-Canine YKL-40 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-YKL-40-Ag01
Product NameCanine YKL-40
Target/BiomarkerCanine YKL-40
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine YKL-40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine YKL-40
Product descriptionRecombinant Canine YKL-40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-YKL-40-Ab01,GMP-CAN-YKL-40-Ab02
Target/BiomarkerCanine YKL-40
Product NameAnti-Canine YKL-40 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine YKL-40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine YKL-40 antibodies in Canine YKL-40 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine YKL-40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine YKL-40 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-YKL-40-Ab03,GMP-CAN-YKL-40-Ab04
Target/BiomarkerCanine YKL-40
Product NameAnti-Canine YKL-40 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine YKL-40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine YKL-40 antibodies in Canine YKL-40 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine YKL-40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine YKL-40, a glycoprotein of approximately 40 kDa, emerges as a fascinating molecular actor in the intricate theater of the canine immune system and tissue physiology. While it shares structural features with chitinases, it notably lacks chitinase activity, setting it apart from its enzymatic counterparts. Its presence is pervasive in various canine tissues, with prominent expression in the liver, kidneys, lungs, and immune cells.

    Structurally, Canine YKL-40 is characterized by its unique chitin-binding domain, which can interact with extracellular matrix components, suggesting a role in tissue remodeling and repair. This glycoprotein's glycosylation also contributes to its stability and modulates its functions, particularly in the context of inflammation.

    The expression of Canine YKL-40 is tightly regulated and can be induced by various pro-inflammatory stimuli. Immune cells, such as macrophages and neutrophils, are prominent sources of YKL-40 production in response to infections and inflammatory signals. This induction reflects its role as a pro-inflammatory mediator and a marker of immune system activation.

    Beyond its involvement in immune responses, Canine YKL-40 has been associated with tissue remodeling processes. In conditions characterized by tissue injury and repair, such as wound healing and fibrosis, YKL-40's interactions with fibroblasts and epithelial cells become particularly relevant. It appears to modulate cellular activities related to extracellular matrix turnover and tissue restructuring.



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