Canine YKL-40 antibody and antigen (recombinant protein)

 Download 

Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-CAN-YKL-40-Ag01	Recombinant Canine YKL-40 protein	3090
GMP-CAN-YKL-40-Ab01	Anti-Canine YKL-40 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-YKL-40-Ab02	Anti-Canine YKL-40 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-YKL-40-Ab03	Anti-Canine YKL-40 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-YKL-40-Ab04	Anti-Canine YKL-40 mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-CAN-YKL-40-Ag01
Product Name	Recombinant Canine YKL-40 protein
Target/Biomarker	Canine Chitinase-3-like protein 1 (YKL-40)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Chitinase-3-like protein 1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Canine YKL-40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-YKL-40-Ab01, GMP-CAN-YKL-40-Ab02, GMP-CAN-YKL-40-Ab03, GMP-CAN-YKL-40-Ab04
Product Name	Anti-Canine YKL-40 mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Chitinase-3-like protein 1 (YKL-40)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Canine Chitinase-3-like protein 1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Canine YKL-40 mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Canine YKL-40, a glycoprotein of approximately 40 kDa, emerges as a fascinating molecular actor in the intricate theater of the canine immune system and tissue physiology. While it shares structural features with chitinases, it notably lacks chitinase activity, setting it apart from its enzymatic counterparts. Its presence is pervasive in various canine tissues, with prominent expression in the liver, kidneys, lungs, and immune cells. Structurally, Canine YKL-40 is characterized by its unique chitin-binding domain, which can interact with extracellular matrix components, suggesting a role in tissue remodeling and repair. This glycoprotein's glycosylation also contributes to its stability and modulates its functions, particularly in the context of inflammation. The expression of Canine YKL-40 is tightly regulated and can be induced by various pro-inflammatory stimuli. Immune cells, such as macrophages and neutrophils, are prominent sources of YKL-40 production in response to infections and inflammatory signals. This induction reflects its role as a pro-inflammatory mediator and a marker of immune system activation. Beyond its involvement in immune responses, Canine YKL-40 has been associated with tissue remodeling processes. In conditions characterized by tissue injury and repair, such as wound healing and fibrosis, YKL-40's interactions with fibroblasts and epithelial cells become particularly relevant. It appears to modulate cellular activities related to extracellular matrix turnover and tissue restructuring.

About GDU