Canine cTnI antibody and antigen (recombinant protein)

Diagnostic anti-Canine cTnI antibodies pairs and antigen for animal health (animal Dog/Canine Myocardial injury, heart disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-cTnI-Ag01Canine cTnI$3090.00
GMP-CAN-cTnI-Ab01Anti-Canine cTnI mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-cTnI-Ab02Anti-Canine cTnI mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-cTnI-Ab03Anti-Canine cTnI human monoclonal antibody (mAb)$3090.00
GMP-CAN-cTnI-Ab04Anti-Canine cTnI human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-cTnI-Ag01
Product NameCanine cTnI
Target/BiomarkerCanine cTnI
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine cTnI antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
TagHis
Reconized/Reactive SpecicsCanine cTnI
Product descriptionRecombinant Canine cTnI protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-cTnI-Ab01,GMP-CAN-cTnI-Ab02
Target/BiomarkerCanine cTnI
Product NameAnti-Canine cTnI mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine cTnI antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine cTnI antibodies in Canine cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
Product descriptionAnti-Canine cTnI mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine cTnI antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-cTnI-Ab03,GMP-CAN-cTnI-Ab04
Target/BiomarkerCanine cTnI
Product NameAnti-Canine cTnI human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine cTnI antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine cTnI antibodies in Canine cTnI level test of animal Dog/Canine with Myocardial injury, heart disease.
Product descriptionAnti-Canine cTnI mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Cardiac Troponin I (cTnI), an integral component of the troponin complex, is a cardiac-specific protein with paramount importance in the context of canine physiology. This protein is predominantly expressed in cardiac muscle cells, setting it apart as a specific biomarker for cardiac health assessment in dogs (canines). To comprehend the significance of cTnI, it is crucial to delve into its structure, function, and role in canine cardiology.

    Structurally, cTnI is part of the troponin complex, which includes two other subunits: cardiac Troponin T (cTnT) and cardiac Troponin C (cTnC). The troponin complex is integral to the regulation of muscle contraction in the heart. Within the sarcomeres of cardiac muscle fibers, cTnI serves as a regulatory protein that, in association with cTnT and cTnC, governs the interactions between actin and myosin, the two key proteins responsible for muscle contraction.

    cTnI's uniqueness lies in its cardiac specificity. While other troponin isoforms exist in skeletal muscle, cTnI is exclusively found in the heart. This exclusivity makes cTnI a highly specific biomarker for cardiac muscle injury or damage. When cardiac cells are injured due to Myocardial injury, heart disease, cardiac diseases, or other factors, cTnI is released into the bloodstream. Thus, the measurement of cTnI levels in a dog's serum can provide critical diagnostic insights into myocardial health.

    Detection of cTnI is typically accomplished through immunoassays, such as enzyme-linked immunosorbent assays (ELISA). These assays allow for the quantitative assessment of cTnI concentration in the blood, enabling veterinarians to gauge the extent of cardiac injury or disease. The sensitivity of these assays is such that even minor cardiac damage can lead to detectable elevations in cTnI levels, facilitating early diagnosis and intervention.



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