Equine TIMP-1 antibody and antigen (recombinant protein)

Diagnostic anti-Equine TIMP-1 antibodies pairs and antigen for animal health (animal Equine/Horse coronary artery stenosis, coronary artery lesions) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Equine disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-EQU-TIMP-1-Ag01Equine TIMP-1$3090.00
GMP-EQU-TIMP-1-Ab01Anti-Equine TIMP-1 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-TIMP-1-Ab02Anti-Equine TIMP-1 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-TIMP-1-Ab03Anti-Equine TIMP-1 human monoclonal antibody (mAb)$3090.00
GMP-EQU-TIMP-1-Ab04Anti-Equine TIMP-1 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-EQU-TIMP-1-Ag01
Product NameEquine TIMP-1
Target/BiomarkerEquine TIMP-1
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Equine TIMP-1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TIMP-1 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
TagHis
Reconized/Reactive SpecicsEquine TIMP-1
Product descriptionRecombinant Equine TIMP-1 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-TIMP-1-Ab01,GMP-EQU-TIMP-1-Ab02
Target/BiomarkerEquine TIMP-1
Product NameAnti-Equine TIMP-1 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Equine TIMP-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine TIMP-1 antibodies in Equine TIMP-1 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
Product descriptionAnti-Equine TIMP-1 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine TIMP-1 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-TIMP-1-Ab03,GMP-EQU-TIMP-1-Ab04
Target/BiomarkerEquine TIMP-1
Product NameAnti-Equine TIMP-1 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Equine TIMP-1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine TIMP-1 antibodies in Equine TIMP-1 level test of animal Equine/Horse with coronary artery stenosis, coronary artery lesions.
Product descriptionAnti-Equine TIMP-1 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    In horses, TIMP-1 demonstrates multifaceted functions beyond its role as a metalloproteinase inhibitor. Extensive research has revealed its involvement in various physiological and pathophysiological processes. TIMP-1 is secreted by different cell types, including fibroblasts, synovial cells, and chondrocytes, and its expression can be regulated by factors such as mechanical stress, growth factors, and cytokines.

    TIMP-1 modulates the balance between extracellular matrix components, such as collagen, elastin, and proteoglycans, by inhibiting the activity of matrix metalloproteinases. This regulation is critical for maintaining tissue homeostasis, preventing excessive matrix degradation, and promoting proper tissue repair.

    Furthermore, TIMP-1 has been implicated in angiogenesis, the process of forming new blood vessels. It influences endothelial cell migration, proliferation, and tube formation, all of which are indispensable for the formation of functional vasculature during wound healing and tissue regeneration in horses.

    Studies have also highlighted the role of TIMP-1 in immune response modulation. It exhibits immunomodulatory effects by influencing leukocyte migration, regulating cytokine production, and modulating the activity of immune cells. This aspect of TIMP-1 function contributes to its involvement in various equine inflammatory diseases and immune-mediated disorders.



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