Equine VDBP antibody and antigen (recombinant protein)

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Diagnostic anti-Equine VDBP antibodies pairs and antigen for animal health (animal Equine/Horse liver failure, type I diabetes, cystic fibrosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

Product Description

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Validation Data

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Target/Biomarker Information

Vitamin D-Binding Protein (VDBP) in horses, or equines, stands as a multifunctional molecular sentinel, bridging the realms of vitamin D metabolism and immune modulation within these majestic animals. Structurally, VDBP is a glycoprotein, weighing in at approximately 58-59 kDa, and it is synthesized predominantly in the liver before making its way into the bloodstream.

Its foremost role in equine physiology revolves around the transportation of vitamin D metabolites, particularly vitamin D3. VDBP acts as a vigilant guardian, binding to vitamin D and ensuring its safe passage through the circulatory system. This chaperone-like function is of paramount importance, as it safeguards vitamin D from rapid degradation, enabling its efficient delivery to target tissues. Vitamin D, once delivered by VDBP, exerts its far-reaching effects, spanning from the regulation of calcium and phosphorus homeostasis, essential for bone health, to its role in modulating immune responses.

In the context of vitamin D metabolism, VDBP acts as the linchpin, orchestrating the journey of vitamin D from its cutaneous or dietary sources to the cells and tissues that rely on it for proper functioning. Whether it's the intestinal absorption of calcium and phosphorus, the mineralization of bone, or the immune system's readiness to respond to challenges, VDBP ensures that vitamin D is where it needs to be when it's needed.

But VDBP's influence transcends mere vitamin D transport. It wears a dual hat, engaging in immunomodulatory activities that underscore its significance in equine health. VDBP has the remarkable capacity to interact with the immune system, primarily through the activation of macrophages and dendritic cells. In doing so, it exerts a regulatory influence on immune responses, particularly those linked to infections and inflammation.

In essence, VDBP connects the dots between vitamin D metabolism and immune functions in horses. It's not just a carrier protein; it's an active participant in the equine immune system. Its ability to modulate immune responses adds a layer of complexity to the understanding of how vitamin D, an essential nutrient, integrates with the immune defenses of these magnificent animals.

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